Higher-order Assemblies in a New Paradigm of Signal Transduction

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2013 Apr 16

PMID 23582320

Citations 183

Authors

Hao Wu

Affiliations

Soon will be listed here.

Abstract

Recent studies have revealed that multiple intracellular signaling proteins may assemble into structured, yet sometimes infinite, higher-order signaling machines for transmission of receptor activation information to cellular responses. These studies advance our understanding of cell signaling and implicate new molecular mechanisms in proximity-driven enzyme activation, threshold behavior, signal amplification, reduction of biological noise, and temporal and spatial control of signal transduction.

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