Changes in Spontaneous Activity Assessed by Accelerometry Correlate with Extent of Cerebral Ischemia-reperfusion Injury in the Nonhuman Primate

Overview

Journal Transl Stroke Res

Publisher Springer

Date 2013 Apr 13

PMID 23580904

Citations 4

Authors

Henryk F Urbanski

Steven G Kohama

G Alexander West

Christine Glynn

Rebecca L Williams-Karnesky

Eric Earl

Martha N Neuringer

Lauren Renner

Alison Weiss

Mary Stenzel-Poore

Frances Rena Bahjat

Affiliations

Soon will be listed here.

Abstract

The use of accelerometry to monitor activity in human stroke patients has revealed strong correlations between objective activity measurements and subjective neurological findings. The goal of our study was to assess the applicability of accelerometry-based measurements in experimental animals undergoing surgically-induced cerebral ischemia. Using a nonhuman primate cortical stroke model, we demonstrate for the first time that monitoring locomotor activity prior to and following cerebrovascular ischemic injury using an accelerometer is feasible in adult male rhesus macaques and that the measured activity outcomes significantly correlate with severity of brain injury. The use of accelerometry as an unobtrusive, objective preclinical efficacy determinant could complement standard practices involving subjective neurological scoring and magnetic resonance imaging in nonhuman primates. Similar activity monitoring devices to those employed in this study are currently in use in human clinical studies, underscoring the feasibility of this approach for assessing the clinical potential of novel treatments for cerebral ischemia.

Citing Articles

Preclinical Development of a Prophylactic Neuroprotective Therapy for the Preventive Treatment of Anticipated Ischemia-Reperfusion Injury.

Bahjat F, West G, Kohama S, Glynn C, Urbanski H, Hobbs T Transl Stroke Res. 2017; 8(4):322-333.

PMID: 28378315 PMC: 5494002. DOI: 10.1007/s12975-017-0532-8.

Locomotor activity and the expression of orexin A and orexin B in aged female rhesus macaques.

Luna S, Brown D, Eghlidi D, Kohama S, Urbanski H Neurobiol Aging. 2016; 50:1-4.

PMID: 27837674 PMC: 5209265. DOI: 10.1016/j.neurobiolaging.2016.10.016.

Impact of moderate calorie restriction on testicular morphology and endocrine function in adult rhesus macaques (Macaca mulatta).

Sitzmann B, Brown D, Garyfallou V, Kohama S, Mattison J, Ingram D Age (Dordr). 2013; 36(1):183-97.

PMID: 23881606 PMC: 3889886. DOI: 10.1007/s11357-013-9563-6.

Steps to translate preconditioning from basic research to the clinic.

Bahjat F, Gesuete R, Stenzel-Poore M Transl Stroke Res. 2013; 4(1):89-103.

PMID: 23504609 PMC: 3595131. DOI: 10.1007/s12975-012-0223-4.

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