The Role of Ceramide-1-phosphate in Biological Functions

Overview

Journal Handb Exp Pharmacol

Specialty Pharmacology

Date 2013 Apr 13

PMID 23579454

Citations 25

Authors

L Alexis Hoeferlin

Dayanjan S Wijesinghe

Charles E Chalfant

Affiliations

Soon will be listed here.

Abstract

In mammalian cells, cermide-1-phosphate (C1P) is produced via the ATP-dependent mechanism of converting ceramide to C1P by the enzyme, ceramide kinase (CERK). CERK was first described as a calcium-stimulated lipid kinase that co-purified with brain synaptic vesicles, and to date, CERK is the only identified mammalian enzyme known to produce C1P in cells. C1P has steadily emerged as a bioactive sphingolipid involved in cell proliferation, macrophage migration, and inflammatory events. The recent generation of the CERK knockout mouse and the development of CERK inhibitors have furthered our current understanding of CERK-derived C1P in regulating biological processes. In this chapter, the history of C1P as well as the biological functions attributed to C1P are reviewed.

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