New Developments in C5a Receptor Signaling

Overview

Journal Cell Health Cytoskelet

Publisher Dove Medical Press

Specialty Cell Biology

Date 2013 Apr 12

PMID 23576881

Citations 37

Authors

J Vidya Sarma

Peter A Ward

Affiliations

Soon will be listed here.

Abstract

Complement activation usually results in the formation of complement fragment 5a (C5a) that interacts with its two receptors, C5aR and C5L2. These receptors belong to the rhodopsin family of G protein-coupled seven transmembrane-containing receptors. C5aR and C5L2 are expressed on/in a wide variety of cells and tissues. Interaction of C5a with C5aR leads to many pleiotropic effects, including the release of cytokines and chemokines and recruitment of inflammatory cells. In certain circumstances, C5a-C5aR interactions can also result in pathophysiological changes as seen in sepsis, rheumatoid arthritis, asthma, acute lung injury and ischemia-reperfusion injury. This overview of the C5a-C5aR interactions describes how such interactions facilitate the pivotal role the complement system plays in the host's innate and adaptive responses.

Citing Articles

Modulation of the hepatic RANK-RANKL-OPG axis by combined C5 and CD14 inhibition in a long-term polytrauma model.

Li Y, Horst K, Greven J, Mert U, Lupu L, Palmer A Front Immunol. 2024; 15:1434274.

PMID: 39640261 PMC: 11617561. DOI: 10.3389/fimmu.2024.1434274.

Complement System and Adhesion Molecule Skirmishes in Fabry Disease: Insights into Pathogenesis and Disease Mechanisms.

Magnusen A, Pandey M Int J Mol Sci. 2024; 25(22).

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PMID: 38979410 PMC: 11229525. DOI: 10.3389/fimmu.2024.1411315.

C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages.

Wright O, Harris A, Nguyen V, Zhou Y, Durand M, Jayyaratnam A Cells. 2023; 12(23).

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Properdin inhibition ameliorates hepatic ischemia/reperfusion injury without interfering with liver regeneration in mice.

Kusakabe J, Hata K, Tajima T, Miyauchi H, Zhao X, Kageyama S Front Immunol. 2023; 14:1174243.

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