Role of P38MAPK and Oxidative Stress in Copper-induced Senescence

Overview

Journal Age (Dordr)

Publisher Springer

Specialty Geriatrics

Date 2013 Apr 12

PMID 23576095

Citations 15

Authors

Emmanuelle Boilan

Virginie Winant

Elise Dumortier

Jean-Pascal Piret

Francois Bonfitto

Heinz D Osiewacz

Florence Debacq-Chainiaux

Olivier Toussaint

Affiliations

Soon will be listed here.

Abstract

In the present work, we indicate that copper is involved in the senescence of human diploid fibroblasts and we describe mechanisms to explain it. Using different techniques, we show for the first time an accumulation of copper in cells during replicative senescence. This accumulation seems to be co-localized with lipofuscin. Second, we observed that an incubation of cells with copper sulfate induced oxidative stress, antioxidant response and premature senescence. Antioxidant molecules reduced the appearance of premature senescence. Third, we found that Nrf2 transcription factor was activated and regulated the expression of genes involved in antioxidant response while p38(MAPK) regulated the appearance of premature senescence.

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