Laminar Analysis of Bicuculline-induced Epileptiform Activity in Area 17 of the Awake Macaque

Overview

Journal Brain Res

Specialty Neurology

Date 1990 May 7

PMID 2357572

Citations 13

Authors

C E Schroeder

C E Tenke

S J Givre

J C Arezzo

H G Vaughan Jr

Affiliations

Soon will be listed here.

Abstract

We investigated the laminar profile of visually evoked paroxysmal discharge following bicuculline administration in area 17 of the alert macaque. Paroxysmal discharge was focussed in lamina 3, with lesser concomitants in infragranular laminae. There were no marked effects on the flash-evoked laminar activation sequence. The neocortex of the alert macaque studied with the present techniques may provide a model for evaluating basic mechanisms of epilepsy, and for linking these to the macroscopic phenomena seen in humans.

Citing Articles

Laminar dynamics of high amplitude beta bursts in human motor cortex.

Bonaiuto J, Little S, Neymotin S, Jones S, Barnes G, Bestmann S Neuroimage. 2021; 242:118479.

PMID: 34407440 PMC: 8463839. DOI: 10.1016/j.neuroimage.2021.118479.

Multiple mechanisms link prestimulus neural oscillations to sensory responses.

Iemi L, Busch N, Laudini A, Haegens S, Samaha J, Villringer A Elife. 2019; 8.

PMID: 31188126 PMC: 6561703. DOI: 10.7554/eLife.43620.

Transient Cognitive Impairment in Epilepsy.

Landi S, Petrucco L, Sicca F, Ratto G Front Mol Neurosci. 2019; 11:458.

PMID: 30666185 PMC: 6330286. DOI: 10.3389/fnmol.2018.00458.

Epileptiform activity in the mouse visual cortex interferes with cortical processing in connected areas.

Petrucco L, Pracucci E, Brondi M, Ratto G, Landi S Sci Rep. 2017; 7:40054.

PMID: 28071688 PMC: 5223162. DOI: 10.1038/srep40054.

Quantification of mid and late evoked sinks in laminar current source density profiles of columns in the primary auditory cortex.

Schaefer M, Hechavarria J, Kossl M Front Neural Circuits. 2015; 9:52.

PMID: 26557058 PMC: 4617414. DOI: 10.3389/fncir.2015.00052.