Tissue-based Identification of Stem Cells and Epithelial-to-mesenchymal Transition in Breast Cancer

Overview

Journal Hum Pathol

Specialty Pathology

Date 2013 Apr 12

PMID 23574782

Citations 12

Authors

Talha E Anwar

Celina G Kleer

Affiliations

Soon will be listed here.

Abstract

Pathologists have recognized breast cancer heterogeneity for decades, but its causes were unknown. In recent years, basic science and translational studies have demonstrated that cancer stem cells contribute to the heterogeneous histologic and functional characteristics of breast cancer. Even more recently, the ability of breast epithelial cells to undergo an epithelial-to-mesenchymal transition has been linked to the acquisition of stem cells properties and enhanced tumor invasion, metastasis, and resistance to available treatments. The stem cells and cells undergoing epithelial-to-mesenchymal transition are attractive targets for therapy and breast cancer prevention. Despite current challenges, their identification in breast tissue samples would enable pathologists to discover and validate prognostic and predictive markers as well as identify markers of increased risk for breast cancer.

Citing Articles

Associations of mammographic breast density with breast stem cell marker-defined breast cancer subtypes.

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A reproducible scaffold-free 3D organoid model to study neoplastic progression in breast cancer.

Djomehri S, Burman B, Gonzalez M, Takayama S, Kleer C J Cell Commun Signal. 2018; 13(1):129-143.

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Limited utility of tissue micro-arrays in detecting intra-tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer.

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Collective invasion in ductal and lobular breast cancer associates with distant metastasis.

Khalil A, Ilina O, Gritsenko P, Bult P, Span P, Friedl P Clin Exp Metastasis. 2017; 34(6-7):421-429.

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Tissue-based associations of mammographic breast density with breast stem cell markers.

Yaghjyan L, Stoll E, Ghosh K, Scott C, Jensen M, Brandt K Breast Cancer Res. 2017; 19(1):100.

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