Inflammatory Myofibroblastic Tumour of the Skull Base

Overview

Journal Case Rep Otolaryngol

Publisher Wiley

Specialty Otorhinolaryngology

Date 2013 Apr 11

PMID 23573442

Citations 13

Authors

Jean-Philippe Maire

Sandrine Eimer

Francois San Galli

Valerie Franco-Vidal

Sigolene Galland-Girodet

Aymeri Huchet

Vincent Darrouzet

Affiliations

Soon will be listed here.

Abstract

Inflammatory myofibroblastic tumors (IMTs) are rare benign clinical and pathological entities. IMTs have been described in the lungs, abdomen, retroperitoneum, and extremities but rarely in the head and neck region. A 38-year-old man presented with headache, right exophthalmia, and right 6th nerve palsy. A CT scan revealed enlargement of the right cavernous sinus and osteolytic lesions of the right sphenoid and clivus. MR imaging showed a large tumor of the skull base which was invading the sella turcica, right cavernous sinus, and sphenoidal sinus. A biopsy was performed and revealed an IMT. Corticosteroids were given for 3 months but were inefficient. In the framework of our pluridisciplinary consultation, fractionated conformal radiotherapy (FRT) was indicated at a low dose; 20 Gy in 10 fractions of 2 Gy over 12 days were delivered. Clinical response was complete 3 months after FRT. Radiological response was subtotal 6 months after FRT. Two years later, the patient is well.

Citing Articles

Chinese Expert Consensus on the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor.

Si X, Wu S, Feng R, Wang X, Guan H, He J Thorac Cancer. 2025; 16(5):e70027.

PMID: 40070347 PMC: 11897609. DOI: 10.1111/1759-7714.70027.

Case report: The role and value of radiotherapy in treatment of inflammatory myofibroblastic tumor.

Guo H, Jiang M, Cai J, Liu R, Yao W, Liang X Front Oncol. 2024; 14:1395787.

PMID: 39619436 PMC: 11604614. DOI: 10.3389/fonc.2024.1395787.

Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment.

Chmiel P, SlOWIKOWSKA A, Banaszek L, Szumera-Cieckiewicz A, Szostakowski B, Spalek M Oncol Res. 2024; 32(7):1141-1162.

PMID: 38948020 PMC: 11209743. DOI: 10.32604/or.2024.050350.

Inflammatory Myofibroblastic Tumor of the Testis in a Patient With Cecal Carcinoma.

Chandramouli R, Sowmya Y, Raghava Ks A, Gochhait D, Jagadesan P Cureus. 2023; 15(9):e44573.

PMID: 37662511 PMC: 10474877. DOI: 10.7759/cureus.44573.

Advanced MRI features of intraventricular inflammatory myofibroblastic tumor: a case report.

Tang X, Huang W, Ma Q, Yi K BMC Neurol. 2022; 22(1):448.

PMID: 36460992 PMC: 9717528. DOI: 10.1186/s12883-022-02993-8.

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