Epigenetic Determinants of Healthy and Diseased Brain Aging and Cognition

Overview

Journal JAMA Neurol

Publisher American Medical Association

Date 2013 Apr 11

PMID 23571692

Citations 42

Authors

Schahram Akbarian

Michal Schnaider Beeri

Vahram Haroutunian

Affiliations

Soon will be listed here.

Abstract

A better understanding of normal and diseased brain aging and cognition will have a significant public health impact, given that the oldest-old persons older than 85 years of age represent the fastest-growing segment in the population in developed countries, with more than 30 million new cases of dementia predicted to occur worldwide each year by 2040. Dysregulation of gene expression and, more generally, genome organization and function are thought to contribute to age-related declines in cognition. Remarkably, nearly all neuronal nuclei that reside in an aged brain had permanently exited from the cell cycle during prenatal development, and DNA methylation and histone modifications and other molecular constituents of the epigenome are likely to play a critical role in the maintenance of neuronal health and function throughout the entire lifespan. Here, we provide an overview of age-related changes in the brain's chromatin structures, highlight potential epigenetic drug targets for cognitive decline and age-related neurodegenerative disease, and discuss opportunities and challenges when studying epigenetic biomarkers in aging research.

Citing Articles

The effect of epigenetic aging on neurodegenerative diseases: a Mendelian randomization study.

Fan J, Liu Q, Liu X, Gong M, Leong I, Tsang Y Front Endocrinol (Lausanne). 2024; 15:1372518.

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Spatial Coding Dysfunction and Network Instability in the Aging Medial Entorhinal Cortex.

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Differential Epigenetic Changes in the Dorsal Hippocampus of Male and Female SAMP8 Mice: A Preliminary Study.

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