Endothelial Junction Regulation: a Prerequisite for Leukocytes Crossing the Vessel Wall

Overview

Journal J Innate Immun

Publisher Karger

Specialty Allergy & Immunology

Date 2013 Apr 11

PMID 23571667

Citations 26

Authors

Anna E Daniel

Jaap D van Buul

Affiliations

Soon will be listed here.

Abstract

The leukocytes of the innate immune system, especially neutrophils and monocytes, exit the circulation early in the response to local inflammation and infection. This is necessary to control and prevent the spread of infections before an adaptive immune response can be raised. The endothelial cells and the intercellular junctions that connect them form a barrier that leukocytes need to pass in order to get to the site of inflammation. The junctions are tightly regulated which ensures that leukocytes only exit when and where they are needed. This regulation is disturbed in many chronic inflammatory diseases which are characterized by ongoing recruitment and interstitial accumulation of leukocytes. In this review, we summarize the molecular mechanisms that regulate endothelial cell-cell junctions and prevent or permit leukocyte transendothelial migration.

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