Effect of Commiphora Mukul Gum Resin on Hepatic Marker Enzymes, Lipid Peroxidation and Antioxidants Status in Pancreas and Heart of Streptozotocin Induced Diabetic Rats

Overview

Journal Asian Pac J Trop Biomed

Specialty Tropical Medicine

Date 2013 Apr 10

PMID 23569867

Citations 26

Authors

B Ramesh

R Karuna

Reddy S Sreenivasa

K Haritha

Mangala D Sai

Bhusana Rao B Sasi

D Saralakumari

Affiliations

Soon will be listed here.

Abstract

Objective: To study the antioxidant efficacy of Commiphora mukul (C. mukul) gum resin ethanolic extract in streptozotocin (STZ) induced diabetic rats.

Methods: THE MALE WISTAR ALBINO RATS WERE RANDOMLY DIVIDED INTO FOUR GROUPS OF EIGHT ANIMALS EACH: Control group (C), CM-treated control group (C+CMEE), Diabetic control group (D), CM- treated diabetic group (D+CMEE). Diabetes was induced by intraperitoneal injection of STZ (55 mg/kg/ bwt). After being confirmed the diabetic rats were treated with C. mukul gum resin ethanolic extract (CMEE) for 60 days. The biochemical estimations like antioxidant, oxidative stress marker enzymes and hepatic marker enzymes of tissues were performed.

Results: The diabetic rats showed increased level of enzymatic activities aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) in liver and kidney and oxidative markers like lipid peroxidation (LPO) and protein oxidation (PO) in pancreas and heart. Antioxidant enzyme activities were significantly decreased in the pancreas and heart compared to control group. Administration of CMEE (200 mg/kg bw) to diabetic rats for 60 days significantly reversed the above parameters towards normalcy.

Conclusions: In conclusion, our data indicate the preventive role of C. mukul against STZ-induced diabetic oxidative stress; hence this plant could be used as an adjuvant therapy for the prevention and/or management of diabetes and aggravated antioxidant status.

Citing Articles

Effects of Red Clover Isoflavones on Growth Performance, Immune Function, and Cecal Microflora of Mice.

Guo R, Song X, Li X, Zeng C, Chen Y, Li C Animals (Basel). 2025; 15(2).

PMID: 39858150 PMC: 11758327. DOI: 10.3390/ani15020150.

Evaluation of the efficicacy of myrcene in the treatment of Eimeria tenella and Toxoplasma gondii infection.

Chen N, Cai Q, Wang S, Song Q, Xie Y, Shi H J Vet Med Sci. 2024; 87(1):32-42.

PMID: 39567006 PMC: 11735216. DOI: 10.1292/jvms.24-0397.

Randomized Clinical Trial of Antioxidant Therapy Patients with Septic Shock and Organ Dysfunction in the ICU: SOFA Score Reduction by Improvement of the Enzymatic and Non-Enzymatic Antioxidant System.

Aisa-Alvarez A, Perez-Torres I, Guarner-Lans V, Manzano-Pech L, Cruz-Soto R, Marquez-Velasco R Cells. 2023; 12(9).

PMID: 37174730 PMC: 10177152. DOI: 10.3390/cells12091330.

Impact of exercise on renal function, oxidative stress, and systemic inflammation among patients with type 2 diabetic nephropathy.

Aldahr M, Abd El-Kader S Afr Health Sci. 2023; 22(3):286-295.

PMID: 36910380 PMC: 9993259. DOI: 10.4314/ahs.v22i3.30.

Effects of against Streptozotocin-Aluminium Chloride Induced Alzheimer's Rats and Their In Silico Study.

Ismail H, Khalid D, Ayub S, Ijaz M, Akram S, Bhatti M Biomed Res Int. 2023; 2023:1725638.

PMID: 36654869 PMC: 9842421. DOI: 10.1155/2023/1725638.

References

Kanth V, Reddy P, Raju T . Attenuation of streptozotocin-induced oxidative stress in hepatic and intestinal tissues of Wistar rat by methanolic-garlic extract. Acta Diabetol. 2008; 45(4):243-51. DOI: 10.1007/s00592-008-0051-x. View

Vozarova B, Stefan N, Lindsay R, Saremi A, Pratley R, Bogardus C . High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes. 2002; 51(6):1889-95. DOI: 10.2337/diabetes.51.6.1889. View

Ellman G . Tissue sulfhydryl groups. Arch Biochem Biophys. 1959; 82(1):70-7. DOI: 10.1016/0003-9861(59)90090-6. View

Bavarva J, Narasimhacharya A . Preliminary study on antihyperglycemic and antihyperlipaemic effects of Butea monosperma in NIDDM rats. Fitoterapia. 2008; 79(5):328-31. DOI: 10.1016/j.fitote.2008.02.009. View

Vlassara H, Palace M . Diabetes and advanced glycation endproducts. J Intern Med. 2002; 251(2):87-101. DOI: 10.1046/j.1365-2796.2002.00932.x. View

Shishodia S, Harikumar K, Dass S, Ramawat K, Aggarwal B . The guggul for chronic diseases: ancient medicine, modern targets. Anticancer Res. 2009; 28(6A):3647-64. View

Ichikawa H, Aggarwal B . Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. Clin Cancer Res. 2006; 12(2):662-8. DOI: 10.1158/1078-0432.CCR-05-1749. View

Ojha S, Bhatia J, Arora S, Golechha M, Kumari S, Arya D . Cardioprotective effects of Commiphora mukul against isoprenaline-induced cardiotoxicity: a biochemical and histopathological evaluation. J Environ Biol. 2012; 32(6):731-8. View

Pavana P, Sethupathy S, Manoharan S . Antihyperglycemic and antilipidperoxidative effects ofTephrosia purpurea seed extract in streptozotocin induced diabetic rats. Indian J Clin Biochem. 2012; 22(1):77-83. PMC: 3454248. DOI: 10.1007/BF02912886. View

10.

Nyenwe E, Jerkins T, Umpierrez G, Kitabchi A . Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes. Metabolism. 2010; 60(1):1-23. PMC: 3746516. DOI: 10.1016/j.metabol.2010.09.010. View

11.

Badole S, Bodhankar S . Antidiabetic activity of cycloart-23-ene-3beta, 25-diol (B2) isolated from Pongamia pinnata (L. Pierre) in streptozotocin-nicotinamide induced diabetic mice. Eur J Pharmacol. 2010; 632(1-3):103-9. DOI: 10.1016/j.ejphar.2010.01.019. View

12.

Maiti R, Jana D, Das U, Ghosh D . Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2004; 92(1):85-91. DOI: 10.1016/j.jep.2004.02.002. View

13.

Eliza J, Daisy P, Ignacimuthu S, Duraipandiyan V . Antidiabetic and antilipidemic effect of eremanthin from Costus speciosus (Koen.)Sm., in STZ-induced diabetic rats. Chem Biol Interact. 2009; 182(1):67-72. DOI: 10.1016/j.cbi.2009.08.012. View

14.

Bellamkonda R, Rasineni K, Singareddy S, Kasetti R, Pasurla R, Chippada A . Antihyperglycemic and antioxidant activities of alcoholic extract of Commiphora mukul gum resin in streptozotocin induced diabetic rats. Pathophysiology. 2011; 18(4):255-61. DOI: 10.1016/j.pathophys.2010.10.002. View

15.

Wang X, Greilberger J, Ledinski G, Kager G, Paigen B, Jurgens G . The hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL. Atherosclerosis. 2004; 172(2):239-46. DOI: 10.1016/j.atherosclerosis.2003.10.008. View

16.

BEERS Jr R, SIZER I . A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem. 1952; 195(1):133-40. View

17.

Levine R, Garland D, Oliver C, Amici A, Climent I, Lenz A . Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 1990; 186:464-78. DOI: 10.1016/0076-6879(90)86141-h. View

18.

Kedziora-Kornatowska K, Szewczyk-Golec K, Kozakiewicz M, Pawluk H, Czuczejko J, Kornatowski T . Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients. J Pineal Res. 2009; 46(3):333-7. DOI: 10.1111/j.1600-079X.2009.00666.x. View

19.

Ramesh B, Saralakumari D . Antihyperglycemic, hypolipidemic and antioxidant activities of ethanolic extract of Commiphora mukul gum resin in fructose-fed male Wistar rats. J Physiol Biochem. 2012; 68(4):573-82. DOI: 10.1007/s13105-012-0175-x. View

20.

Karuna R, Bharathi V, Reddy S, Ramesh B, Saralakumari D . Protective effects of Phyllanthus amarus aqueous extract against renal oxidative stress in Streptozotocin -induced diabetic rats. Indian J Pharmacol. 2011; 43(4):414-8. PMC: 3153704. DOI: 10.4103/0253-7613.83112. View