Glucose-6-phosphate-dehydrogenase Deficiency and Its Correlation with Other Risk Factors in Jaundiced Newborns in Southern Brazil

Overview

Journal Asian Pac J Trop Biomed

Specialty Tropical Medicine

Date 2013 Apr 10

PMID 23569738

Citations 6

Authors

Clarissa Gutierrez Carvalho

Simone Martins Castro

Ana Paula Santin

Carina Zaleski

Felipe Gutierrez Carvalho

Roberto Giugliani

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the correlation between glucose-6-phosphate-dehydrogenase (G6PD) deficiency and neonatal jaundice.

Methods: Prospective, observational case-control study was conducted on 490 newborns admitted to Hospital de Clínicas de Porto Alegre for phototherapy, who all experienced 35 or more weeks of gestation, from March to December 2007. Enzymatic screening of G6PD activity was performed, followed by PCR.

Results: There was prevalence of 4.6% and a boy-girl ratio of 3:1 in jaundiced newborns. No jaundiced neonate with ABO incompatibility presented G6PD deficiency, and no Mediterranean mutation was found. A higher proportion of deficiency was observed in Afro-descendants. There was no association with UGT1A1 variants.

Conclusions: G6PD deficiency is not related to severe hyperbilirubinemia and considering the high miscegenation in this area of Brazil, other gene interactions should be investigated.

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