Gynecologic Bleeding Revealing Vaginal Metastasis of Renal Cell Carcinoma

Overview

Journal Pan Afr Med J

Date 2013 Apr 9

PMID 23565309

Citations 9

Authors

Zineb Benbrahim

Ali Chouaib

Renaud Mazeron

Marie Benedicte Leger-Ravet

Catherine Lefort

Catherine Lhomme

Omar El Mesbahi

Bernard Escudier

Affiliations

Soon will be listed here.

Abstract

Vaginal metastases of renal cell carcinoma have been rarely described. We report a case of a 75-year old woman, who underwent radical right nephrectomy for a renal cell carcinoma. Tumour was classified pT3bN0M0 and grade III of Furhmann grading. One year later, scanner discovered mediastinal and lombo-aortic lymph nodes. She received 2 months of immunotherapy associated with bevacizumab, but stopped because of intolerance. She was readmitted in our institute for vaginal bleeding. Clinical investigations showed a vaginal mass and biopsy revealed a renal cell carcinoma metastasis. This case suggests that retrograde venous dissemination may be at the origin of vaginal metastasis of renal cell carcinoma and emphasized the preventive value of early ligature of renal vein.

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References

Allard J, McBroom J, Zahn C, McLeod D, Maxwell G . Vaginal metastasis and thrombocytopenia from renal cell carcinoma. Gynecol Oncol. 2004; 92(3):970-3. DOI: 10.1016/j.ygyno.2003.11.046. View

Saussine C, Delepaul B, Jacqmin D . [Vaginal metastasis from cancer of the kidney]. Prog Urol. 1994; 4(1):95-7. View

Tarraza Jr H, Meltzer S, DeCain M, Jones M . Vaginal metastases from renal cell carcinoma: report of four cases and review of the literature. Eur J Gynaecol Oncol. 1998; 19(1):14-8. View

Mendese G, Ayvazian P, Li C . Renal cell carcinoma presenting as a perineal mass: case report and review of the literature. Urology. 2006; 67(4):847.e1-2. DOI: 10.1016/j.urology.2005.10.047. View

Mulcahy J, Furlow W . Vaginal metastasis from renal cell carcinoma: radiographic evidence of possible route of spread. J Urol. 1970; 104(1):50-2. DOI: 10.1016/s0022-5347(17)61669-0. View