Efficient Synthesis of [18F]trifluoromethane and Its Application in the Synthesis of PET Tracers

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2013 Apr 9

PMID 23563284

Citations 12

Authors

Dion van der Born

J Koos D M Herscheid

Romano V A Orru

Danielle J Vugts

Affiliations

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Abstract

A new strategy towards [(18)F]trifluoromethyl-containing compounds is developed. [(18)F]trifluoromethane is synthesised in a fast and efficient manner and subsequently used in the reaction with aldehydes and ketones forming [(18)F]trifluoromethyl carbinols in good yields.

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