Intervention Strategies for Emerging Viruses: Use of Antivirals

Overview

Journal Curr Opin Virol

Publisher Elsevier

Specialty Microbiology

Date 2013 Apr 9

PMID 23562753

Citations 18

Authors

Yannick Debing

Dirk Jochmans

Johan Neyts

Affiliations

Soon will be listed here.

Abstract

Today, small molecule antiviral drugs are available for the treatment of infections with herpesviruses, HIV, HBV and HCV as well as with influenza viruses. Ribavirin, a broad-spectrum (but aspecific) antiviral, has been approved for the treatment of infections with respiratory syncytial virus, HCV and Lassa virus. Yet, for many other viruses that cause life-threatening infections [most of which are considered emerging and/or neglected] there are no drugs available. Ideally, potent and broad-spectrum (i.e., pan-genus or pan-family virus activity) antiviral drugs should be developed whereby one drug could be used for the treatment of a number of such viral infections. We here review recent evolutions in the search for inhibitors of emerging and neglected RNA viruses.

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