[Vitamin D and Breast Cancer: is There a Link?]
Overview
Reproductive Medicine
Authors
Affiliations
Objective: The aim of this review is to know the relationship between breast cancer and vitamin D, synthesised by skin or brought by food or supplementation.
Material And Methods: The selected articles were extracted from the Pubmed database between 1998 and 2012. The keywords used were: "25-hydroxyvitamin D", "breast cancer recurrence", "breast cancer risk", "serum levels of vitamin D", "vitamin D intake". A total of 37 articles were selected.
Results: The sun exposure, via the skin vitamin D synthesis, is associated with a decreased risk of breast cancer. This decrease seems also likely for food contributions and an over 400IU per day vitamin D supplementation. An inverse relationship between plasma 25-hydroxyvitamin D (25-OH-D) level and breast cancer risk has been suggested. An increased 25-OH-D level seems associated with a decreased risk of breast cancer recurrence.
Conclusion: Recommendations concerning a vitamin D supplementation could be established, but should be supported by additional studies.
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The association between Vitamin D and health outcomes in women: A review on the related evidence.
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PMID: 27904621 PMC: 5122178. DOI: 10.4103/1735-1995.189693.