Channelopathies from Mutations in the Cardiac Sodium Channel Protein Complex

Overview

Journal J Mol Cell Cardiol

Specialty Cardiology & Vascular Diseases

Date 2013 Apr 6

PMID 23557754

Citations 25

Authors

Graham S Adsit

Ravi Vaidyanathan

Carla M Galler

John W Kyle

Jonathan C Makielski

Affiliations

Soon will be listed here.

Abstract

The cardiac sodium current underlies excitability in heart, and inherited abnormalities of the proteins regulating and conducting this current cause inherited arrhythmia syndromes. This review focuses on inherited mutations in non-pore forming proteins of sodium channel complexes that cause cardiac arrhythmia, and the deduced mechanisms by which they affect function and dysfunction of the cardiac sodium current. Defining the structure and function of these complexes and how they are regulated will contribute to understanding the possible roles for this complex in normal and abnormal physiology and homeostasis. This article is part of a Special Issue entitled "Na(+) Regulation in Cardiac Myocytes".

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