Requirement for Core 2 O-glycans for Optimal Resistance to Helminth Infection

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Apr 5

PMID 23555902

Citations 4

Authors

Sarah C Mullaly

Menno J Oudhoff

Paul H Min

Kyle Burrows

Frann Antignano

David G Rattray

Alistair Chenery

Kelly M McNagny

Hermann J Ziltener

Colby Zaph

Affiliations

Soon will be listed here.

Abstract

The migration of lymphocytes to the small intestine is controlled by expression of the integrin α4β7 and the chemokine receptor CCR9. However, the molecules that specifically regulate migration to the large intestine remain unclear. Immunity to infection with the large intestinal helminth parasite Trichuris muris is dependent upon CD4(+) T cells that migrate to the large intestine. We examine the role of specific chemokine receptors, adhesion molecules and glycosyltransferases in the development of protective immunity to Trichuris. Mice deficient in expression of the chemokine receptors CCR2 or CCR6 were resistant to infection with Trichuris. Similarly, loss of CD34, CD43, CD44 or PSGL-1 had no effect on resistance to infection. In contrast, simultaneous deletion of the Core2 β1,6-N-acetylglucosaminyltransferase (C2GnT) enzymes C2GnT1 and C2Gnt2 resulted in delayed expulsion of worms. These results suggest that C2GnT-dependent modifications may play a role in migration of protective immune cells to the large intestine.

Citing Articles

Helminths and intestinal barrier function.

McKay D, Shute A, Lopes F Tissue Barriers. 2017; 5(1):e1283385.

PMID: 28452686 PMC: 5362995. DOI: 10.1080/21688370.2017.1283385.

CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue.

Bolus W, Gutierrez D, Kennedy A, Anderson-Baucum E, Hasty A J Leukoc Biol. 2015; 98(4):467-77.

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Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation.

Little M, Hurst R, Else K J Immunol. 2014; 193(9):4684-95.

PMID: 25261482 PMC: 4201944. DOI: 10.4049/jimmunol.1400502.

Immunity to gastrointestinal nematodes: mechanisms and myths.

Grencis R, Humphreys N, Bancroft A Immunol Rev. 2014; 260(1):183-205.

PMID: 24942690 PMC: 4141702. DOI: 10.1111/imr.12188.

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