Prenatal Exposure to a Polychlorinated Biphenyl (PCB) Congener Influences Fixation Duration on Biological Motion at 4-months-old: a Preliminary Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Apr 5

PMID 23555630

Citations 7

Authors

Hirokazu Doi

Shota Nishitani

Takashi X Fujisawa

Tomoko Nagai

Masaki Kakeyama

Takahiro Maeda

Kazuyuki Shinohara

Affiliations

Soon will be listed here.

Abstract

Adverse effects of prenatal exposure to polychlorinated biphenyl (PCB) congeners on postnatal brain development have been reported in a number of previous studies. However, few studies have examined the effects of prenatal PCB exposure on early social development. The present study sought to increase understanding of the neurotoxicity of PCBs by examining the relationship between PCB congener concentrations in umbilical cord blood and fixation patterns when observing upright and inverted biological motion (BM) at four-months after birth. The development of the ability to recognize BM stimuli is considered a hallmark of socio-cognitive development. The results revealed a link between dioxin-like PCB #118 concentration and fixation pattern. Specifically, four-month-olds with a low-level of prenatal exposure to PCB #118 exhibited a preference for the upright BM over inverted BM, whereas those with a relatively high-level of exposure did not. This finding supports the proposal that prenatal PCB exposure impairs the development of social functioning, and indicates the importance of congener-specific analysis in the risk analysis of the adverse effects of PCB exposure on the brain development.

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References

Knerr S, Schrenk D . Carcinogenicity of "non-dioxinlike" polychlorinated biphenyls. Crit Rev Toxicol. 2006; 36(9):663-94. DOI: 10.1080/10408440600845304. View

McEwen B, Alves S . Estrogen actions in the central nervous system. Endocr Rev. 1999; 20(3):279-307. DOI: 10.1210/edrv.20.3.0365. View

Rogan W, Gladen B . Breast-feeding and cognitive development. Early Hum Dev. 1993; 31(3):181-93. DOI: 10.1016/0378-3782(93)90194-y. View

Schantz S, Widholm J, Rice D . Effects of PCB exposure on neuropsychological function in children. Environ Health Perspect. 2003; 111(3):357-576. PMC: 1241394. DOI: 10.1289/ehp.5461. View

Pavlova M . Biological motion processing as a hallmark of social cognition. Cereb Cortex. 2011; 22(5):981-95. DOI: 10.1093/cercor/bhr156. View

Gladen B, Rogan W, Hardy P, Thullen J, Tingelstad J, Tully M . Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk. J Pediatr. 1988; 113(6):991-5. DOI: 10.1016/s0022-3476(88)80569-9. View

McCarthy M . Estradiol and the developing brain. Physiol Rev. 2008; 88(1):91-124. PMC: 2754262. DOI: 10.1152/physrev.00010.2007. View

Guo Y, Lai T, Chen S, Hsu C . Gender-related decrease in Raven's progressive matrices scores in children prenatally exposed to polychlorinated biphenyls and related contaminants. Bull Environ Contam Toxicol. 1995; 55(1):8-13. DOI: 10.1007/BF00212382. View

Jacobson J, Jacobson S . Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med. 1996; 335(11):783-9. DOI: 10.1056/NEJM199609123351104. View

10.

Pavlova M, Sokolov A . Orientation specificity in biological motion perception. Percept Psychophys. 2000; 62(5):889-99. DOI: 10.3758/bf03212075. View

11.

Birch E, Birch D, Hoffman D, Hale L, Everett M, Uauy R . Breast-feeding and optimal visual development. J Pediatr Ophthalmol Strabismus. 1993; 30(1):33-8. DOI: 10.3928/0191-3913-19930101-09. View

12.

Park J, Bergman A, Linderholm L, Athanasiadou M, Kocan A, Petrik J . Placental transfer of polychlorinated biphenyls, their hydroxylated metabolites and pentachlorophenol in pregnant women from eastern Slovakia. Chemosphere. 2007; 70(9):1676-84. PMC: 2703177. DOI: 10.1016/j.chemosphere.2007.07.049. View

13.

Hirai M, Fukushima H, Hiraki K . An event-related potentials study of biological motion perception in humans. Neurosci Lett. 2003; 344(1):41-4. DOI: 10.1016/s0304-3940(03)00413-0. View

14.

Cao Y, Winneke G, Wilhelm M, Wittsiepe J, Lemm F, Furst P . Environmental exposure to dioxins and polychlorinated biphenyls reduce levels of gonadal hormones in newborns: results from the Duisburg cohort study. Int J Hyg Environ Health. 2007; 211(1-2):30-9. DOI: 10.1016/j.ijheh.2007.04.005. View

15.

Klin A, Jones W . Altered face scanning and impaired recognition of biological motion in a 15-month-old infant with autism. Dev Sci. 2008; 11(1):40-6. DOI: 10.1111/j.1467-7687.2007.00608.x. View

16.

Doi H, Koga T, Shinohara K . 18-Month-olds can perceive Mooney faces. Neurosci Res. 2009; 64(3):317-22. DOI: 10.1016/j.neures.2009.04.002. View

17.

Forns J, Torrent M, Garcia-Esteban R, Grellier J, Gascon M, Julvez J . Prenatal exposure to polychlorinated biphenyls and child neuropsychological development in 4-year-olds: an analysis per congener and specific cognitive domain. Sci Total Environ. 2012; 432:338-43. DOI: 10.1016/j.scitotenv.2012.06.012. View

18.

Miyashita C, Sasaki S, Saijo Y, Washino N, Okada E, Kobayashi S . Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy. Environ Res. 2011; 111(4):551-8. DOI: 10.1016/j.envres.2011.01.021. View

19.

Gladen B, Ragan N, Rogan W . Pubertal growth and development and prenatal and lactational exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene. J Pediatr. 2001; 136(4):490-6. DOI: 10.1016/s0022-3476(00)90012-x. View

20.

Sumi S . Upside-down presentation of the Johansson moving light-spot pattern. Perception. 1984; 13(3):283-6. DOI: 10.1068/p130283. View