PET Imaging for Receptor Occupancy: Meditations on Calculation and Simplification

Overview

Journal J Biomed Res

Specialty General Medicine

Date 2013 Apr 5

PMID 23554733

Citations 17

Authors

Yumin Zhang

Gerard B Fox

Affiliations

Soon will be listed here.

Abstract

This invited mini-review briefly summarizes procedures and challenges of measuring receptor occupancy with positron emission tomography. Instead of describing the detailed analytic procedures of in vivo ligand-receptor imaging, the authors provide a pragmatic approach, along with personal perspectives, for conducting positron emission tomography imaging for receptor occupancy, and systematically elucidate the mathematics of receptor occupancy calculations in practical ways that can be understood with elementary algebra. The authors also share insights regarding positron emission tomography imaging for receptor occupancy to facilitate applications for the development of drugs targeting receptors in the central nervous system.

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