Epidemiological Interpretation of Studies Examining the Effect of Antibiotic Usage on Resistance

Overview

Journal Clin Microbiol Rev

Publisher American Society for Microbiology

Specialty Microbiology

Date 2013 Apr 5

PMID 23554418

Citations 70

Authors

Vered Schechner

Elizabeth Temkin

Stephan Harbarth

Yehuda Carmeli

Mitchell J Schwaber

Affiliations

Soon will be listed here.

Abstract

Bacterial resistance to antibiotics is a growing clinical problem and public health threat. Antibiotic use is a known risk factor for the emergence of antibiotic resistance, but demonstrating the causal link between antibiotic use and resistance is challenging. This review describes different study designs for assessing the association between antibiotic use and resistance and discusses strengths and limitations of each. Approaches to measuring antibiotic use and antibiotic resistance are presented. Important methodological issues such as confounding, establishing temporality, and control group selection are examined.

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