Recent Advances in the Molecular Basis of Anti-neoplastic Mechanisms of Oridonin

Overview

Journal Chin J Integr Med

Date 2013 Apr 3

PMID 23546635

Citations 14

Authors

Wei Tian

Si-Yu Chen

Affiliations

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Abstract

Oridonin, a diterpenoid isolated from Rabdosia rubescens, has been proven to possess various pharmacological and physiological effects such as anti-inflammation, anti-bacterial, and anti-neoplastic, although in recent years, more attention has been paid to its anti-neoplastic effects. For example, oridonin can trigger cell cycle arrest, apoptosis, and autophagy in different neoplastic cell lines. This review summarizes the considerable knowledge about the action mechanisms of oridonin that has been studied in recent years. The present observations reveal the novel anti-neoplastic effects of oridonin, suggesting that it may be effective as a potent alternative or adjunct drug to conventional chemotherapy.

Citing Articles

Oridonin Induces Apoptosis in Esophageal Squamous Cell Carcinoma by Inhibiting Cytoskeletal Protein LASP1 and PDLIM1.

Zhang X, Xing M, Ma Y, Zhang Z, Qiu C, Wang X Molecules. 2023; 28(2).

PMID: 36677861 PMC: 9862004. DOI: 10.3390/molecules28020805.

Oridonin Attenuates Lipopolysaccharide-Induced ROS Accumulation and Inflammation in HK-2 Cells.

Huang J, Lan C, Hsu Y, Tsai C, Tzeng I, Wang P Evid Based Complement Alternat Med. 2020; 2020:9724520.

PMID: 32184902 PMC: 7063205. DOI: 10.1155/2020/9724520.

Solubility and Bioavailability Enhancement of Oridonin: A Review.

Zhang Y, Wang S, Dai M, Nai J, Zhu L, Sheng H Molecules. 2020; 25(2).

PMID: 31947574 PMC: 7024198. DOI: 10.3390/molecules25020332.

Natural Compound Oridonin Inhibits Endotoxin-Induced Inflammatory Response of Activated Hepatic Stellate Cells.

Cummins C, Wang X, Sommerhalder C, Bohanon F, Nunez Lopez O, Tie H Biomed Res Int. 2019; 2018:6137420.

PMID: 30687752 PMC: 6330820. DOI: 10.1155/2018/6137420.

Phytotherapeutics Oridonin and Ponicidin show Additive Effects Combined with Irradiation in Pancreatic Cancer .

Liermann J, Naumann P, Fortunato F, Schmid T, Weber K, Debus J Radiol Oncol. 2018; 51(4):407-414.

PMID: 29333119 PMC: 5765317. DOI: 10.1515/raon-2017-0048.

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