Overexpression of AIB1 Correlates Inversely with E-cadherin Expression in Pancreatic Adenocarcinoma and May Promote Lymph Node Metastasis

Overview

Journal Int J Clin Oncol

Specialty Oncology

Date 2013 Apr 2

PMID 23542947

Citations 11

Authors

Si Guo

Jingjing Xu

Rui Xue

Yuqiong Liu

Haibo Yu

Affiliations

Soon will be listed here.

Abstract

Background: It was reported that the nuclear receptor coactivator amplified in breast cancer1 (AIB1) could regulate cancer cell invasion and migration in a nuclear receptor signaling-independent manner. Meanwhile, the process of epithelial mesenchymal transition (EMT) is critical for tumor invasion and metastasis. The present study aimed to determine the role of AIB1 and EMT markers in human pancreatic adenocarcinoma.

Methods: AIB1, ZO-1, E-cadherin, vimentin, and N-cadherin protein expression in 76 pancreatic adenocarcinomas were assessed using immunohistochemistry and analyzed for clinicopathological significance.

Results: The frequency of AIB1 overexpression in pancreatic adenocarcinomas with lymph node metastasis is 68 % (19/28), which is significantly higher than in pancreatic adenocarcinomas without lymph node metastasis (42 %; 20/48). In addition, the frequency of low expression of E-cadherin in pancreatic carcinomas with lymph node metastasis (68 %; 19/28) was significantly higher than in tumors without lymph node metastasis (44 %; 21/48). Correlation analysis demonstrated that the overexpression of AIB1 was inversely correlated with low expression of E-cadherin in pancreatic adenocarcinomas.

Conclusion: Overexpression of AIB1 might promote invasion and metastasis of cancer cells and is associated with down-regulation of E-cadherin in pancreatic adenocarcinomas.

Citing Articles

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Prognostic and Clinicopathological Significance of E-Cadherin in Pancreatic Cancer Patients: A Meta-Analysis.

Wang P, Zhu Z Front Oncol. 2021; 11:627116.

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Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype.

Vareslija D, Ward E, Purcell S, Cosgrove N, Cocchiglia S, OHalloran P Oncogene. 2021; 40(7):1318-1331.

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Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C-X-C motif chemokine receptor 4.

He L, Deng H, Liu S, Chen J, Li B, Wang C Cancer Commun (Lond). 2018; 38(1):53.

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Upregulated N-cadherin expression is associated with poor prognosis in epithelial-derived solid tumours: A meta-analysis.

Luo Y, Yu T, Zhang Q, Fu Q, Hu Y, Xiang M Eur J Clin Invest. 2018; 48(4).

PMID: 29405291 PMC: 5887888. DOI: 10.1111/eci.12903.

References

Wang Y, Wu M, Sham J, Zhang W, Wu W, Guan X . Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma. A broad survey using high-throughput tissue microarray. Cancer. 2002; 95(11):2346-52. DOI: 10.1002/cncr.10963. View

Kuang S, Liao L, Zhang H, Lee A, OMalley B, Xu J . AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res. 2004; 64(5):1875-85. DOI: 10.1158/0008-5472.can-03-3745. View

Cavallaro U, Christofori G . Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer. 2004; 4(2):118-32. DOI: 10.1038/nrc1276. View

Colo G, Rosato R, Grant S, Costas M . RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis. FEBS Lett. 2007; 581(26):5075-81. DOI: 10.1016/j.febslet.2007.09.052. View

Laheru D, Jaffee E . Immunotherapy for pancreatic cancer - science driving clinical progress. Nat Rev Cancer. 2005; 5(6):459-67. DOI: 10.1038/nrc1630. View

Chung A, Zhou S, Liao L, Tien J, Greenberg N, Xu J . Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice. Cancer Res. 2007; 67(12):5965-75. PMC: 2898573. DOI: 10.1158/0008-5472.CAN-06-3168. View

Yan J, Erdem H, Li R, Cai Y, Ayala G, Ittmann M . Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression. Cancer Res. 2008; 68(13):5460-8. PMC: 2826835. DOI: 10.1158/0008-5472.CAN-08-0955. View

Thiery J . Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002; 2(6):442-54. DOI: 10.1038/nrc822. View

He L, Liu M, Li B, Rao H, Deng H, Guan X . Overexpression of AIB1 predicts resistance to chemoradiotherapy and poor prognosis in patients with primary esophageal squamous cell carcinoma. Cancer Sci. 2009; 100(9):1591-6. PMC: 11158532. DOI: 10.1111/j.1349-7006.2009.01224.x. View

10.

Li L, Louie M, Chen H, Zou J . Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression. Cancer Lett. 2007; 261(1):64-73. DOI: 10.1016/j.canlet.2007.11.013. View

11.

Baygi M, Soheili Z, Schmitz I, Sameie S, Schulz W . Snail regulates cell survival and inhibits cellular senescence in human metastatic prostate cancer cell lines. Cell Biol Toxicol. 2010; 26(6):553-67. DOI: 10.1007/s10565-010-9163-5. View

12.

Henke R, Haddad B, Kim S, Rone J, Mani A, Jessup J . Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma. Clin Cancer Res. 2004; 10(18 Pt 1):6134-42. DOI: 10.1158/1078-0432.CCR-04-0561. View

13.

Anzick S, Kononen J, Walker R, Azorsa D, TANNER M, Guan X . AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science. 1997; 277(5328):965-8. DOI: 10.1126/science.277.5328.965. View

14.

Liu M, Xie D, Mai S, Tong Z, Shao J, Fu Y . Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage. Am J Clin Pathol. 2008; 129(5):728-34. DOI: 10.1309/QMDTL82JKEX6E7H2. View

15.

Polyak K, Weinberg R . Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 2009; 9(4):265-73. DOI: 10.1038/nrc2620. View

16.

Qin L, Liao L, Redmond A, Young L, Yuan Y, Chen H . The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression. Mol Cell Biol. 2008; 28(19):5937-50. PMC: 2547002. DOI: 10.1128/MCB.00579-08. View

17.

Christiansen J, Rajasekaran A . Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res. 2006; 66(17):8319-26. DOI: 10.1158/0008-5472.CAN-06-0410. View

18.

Pignatelli M, Ansari T, Gunter P, Liu D, Hirano S, Takeichi M . Loss of membranous E-cadherin expression in pancreatic cancer: correlation with lymph node metastasis, high grade, and advanced stage. J Pathol. 1994; 174(4):243-8. DOI: 10.1002/path.1711740403. View

19.

Sakaguchi H, Fujimoto J, Sun W, Tamaya T . Clinical implications of steroid receptor coactivator (SRC)-3 in uterine endometrial cancers. J Steroid Biochem Mol Biol. 2007; 104(3-5):237-40. DOI: 10.1016/j.jsbmb.2007.03.007. View

20.

Yoshida H, Liu J, Samuel S, Cheng W, Rosen D, Naora H . Steroid receptor coactivator-3, a homolog of Taiman that controls cell migration in the Drosophila ovary, regulates migration of human ovarian cancer cells. Mol Cell Endocrinol. 2005; 245(1-2):77-85. DOI: 10.1016/j.mce.2005.10.008. View