Negative Life Events and Corticotropin-releasing-hormone Receptor1 Gene in Recurrent Major Depressive Disorder

Overview

Journal Sci Rep

Specialty Science

Date 2013 Mar 27

PMID 23529111

Citations 15

Authors

Zhongchun Liu

Wanhong Liu

Lihua Yao

Can Yang

Ling Xiao

Qirong Wan

Kai Gao

Huiling Wang

Fan Zhu

Gaohua Wang

Zheman Xiao

Affiliations

Soon will be listed here.

Abstract

Major depressive disorder (MDD) is a long-term, recurrent condition that often takes a chronic course. It seems imperative that research should be focused on gaining a better understanding of what predicts recurrent MDD. As a major mediator of the stress response, corticotropin-releasing-hormone receptor 1 (CRHR1) has been demonstrated to be an important contributor to the pathogenesis of MDD. In this study, we show a significant increase in the G-allele (rs242939) of the CRHR1 gene in the recurrent MDD group compared with the control group, and an overrepresentation of G-G-T hyplotype of the CRHR1 gene in recurrent MDD. We also demonstrate the interaction of the CRHR1 gene and negative life events in recurrent MDD. These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood.

Citing Articles

Examining hypothalamic-pituitary-adrenal axis genetic variation on cortisol and alpha-amylase reactivity during an explicit negative-evaluative stress induction.

Grillo A, Starr L, Vrshek-Schallhorn S Stress Health. 2024; 40(6):e3484.

PMID: 39365170 PMC: 11636444. DOI: 10.1002/smi.3484.

Proposed Physiological Mechanisms Underlying the Association between Adverse Childhood Experiences and Mental Health Conditions: A Narrative Review.

Kurbatfinski S, Dosani A, Dewey D, Letourneau N Children (Basel). 2024; 11(9).

PMID: 39334644 PMC: 11430311. DOI: 10.3390/children11091112.

Genetic Landscape of Major Depressive Disorder: Assessment of Potential Diagnostic and Antidepressant Response Markers.

Singh P, Srivastava A, Guin D, Thakran S, Yadav J, Chandna P Int J Neuropsychopharmacol. 2023; 26(10):692-738.

PMID: 36655406 PMC: 10586057. DOI: 10.1093/ijnp/pyad001.

Genome-wide by Environment Interaction Study of Stressful Life Events and Hospital-Treated Depression in the iPSYCH2012 Sample.

Suppli N, Andersen K, Agerbo E, Rajagopal V, Appadurai V, Coleman J Biol Psychiatry Glob Open Sci. 2022; 2(4):400-410.

PMID: 36324662 PMC: 9616262. DOI: 10.1016/j.bpsgos.2021.11.003.

Spinal pain in employees exposed to abusive supervision: Evidence of a sex and CRHR1 CTC haplotype interaction.

Sannes A, Risoy A, Christensen J, Nielsen M, Gjerstad J Mol Pain. 2021; 17:17448069211042123.

PMID: 34617831 PMC: 8504651. DOI: 10.1177/17448069211042123.

References

Heim C, Mletzko T, Purselle D, Musselman D, Nemeroff C . The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma. Biol Psychiatry. 2007; 63(4):398-405. DOI: 10.1016/j.biopsych.2007.07.002. View

Caspi A, Hariri A, Holmes A, Uher R, Moffitt T . Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry. 2010; 167(5):509-27. PMC: 2943341. DOI: 10.1176/appi.ajp.2010.09101452. View

Brewin C, Andrews B, Gotlib I . Psychopathology and early experience: a reappraisal of retrospective reports. Psychol Bull. 1993; 113(1):82-98. DOI: 10.1037/0033-2909.113.1.82. View

Lou X, Chen G, Yan L, Ma J, Zhu J, Elston R . A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet. 2007; 80(6):1125-37. PMC: 1867100. DOI: 10.1086/518312. View

Kendler K, Karkowski L, Prescott C . Stressful life events and major depression: risk period, long-term contextual threat, and diagnostic specificity. J Nerv Ment Dis. 1998; 186(11):661-9. DOI: 10.1097/00005053-199811000-00001. View

Rice F, Harold G, Thapar A . Negative life events as an account of age-related differences in the genetic aetiology of depression in childhood and adolescence. J Child Psychol Psychiatry. 2003; 44(7):977-87. DOI: 10.1111/1469-7610.00182. View

Fisher H, Craig T, Fearon P, Morgan K, Dazzan P, Lappin J . Reliability and comparability of psychosis patients' retrospective reports of childhood abuse. Schizophr Bull. 2009; 37(3):546-53. PMC: 3080697. DOI: 10.1093/schbul/sbp103. View

Chen R, Lewis K, PERRIN M, Vale W . Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci U S A. 1993; 90(19):8967-71. PMC: 47482. DOI: 10.1073/pnas.90.19.8967. View

Monroe S, Slavich G, Torres L, Gotlib I . Major life events and major chronic difficulties are differentially associated with history of major depressive episodes. J Abnorm Psychol. 2007; 116(1):116-24. PMC: 3631311. DOI: 10.1037/0021-843X.116.1.116. View

10.

Manolio T, Collins F, Cox N, Goldstein D, Hindorff L, Hunter D . Finding the missing heritability of complex diseases. Nature. 2009; 461(7265):747-53. PMC: 2831613. DOI: 10.1038/nature08494. View

11.

Kessler R . The effects of stressful life events on depression. Annu Rev Psychol. 1997; 48:191-214. DOI: 10.1146/annurev.psych.48.1.191. View

12.

Juhasz G, Dunham J, McKie S, Thomas E, Downey D, Chase D . The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. Biol Psychiatry. 2011; 69(8):762-71. DOI: 10.1016/j.biopsych.2010.11.019. View

13.

Cicchetti D, Rogosch F, Oshri A . Interactive effects of corticotropin releasing hormone receptor 1, serotonin transporter linked polymorphic region, and child maltreatment on diurnal cortisol regulation and internalizing symptomatology. Dev Psychopathol. 2011; 23(4):1125-38. PMC: 3696510. DOI: 10.1017/S0954579411000599. View

14.

Uher R, McGuffin P . The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol Psychiatry. 2009; 15(1):18-22. DOI: 10.1038/mp.2009.123. View

15.

Holmes T, RAHE R . The Social Readjustment Rating Scale. J Psychosom Res. 1967; 11(2):213-8. DOI: 10.1016/0022-3999(67)90010-4. View

16.

Raadsheer F, Hoogendijk W, STAM F, Tilders F, Swaab D . Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology. 1994; 60(4):436-44. DOI: 10.1159/000126778. View

17.

Risch N, Herrell R, Lehner T, Liang K, Eaves L, Hoh J . Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA. 2009; 301(23):2462-71. PMC: 2938776. DOI: 10.1001/jama.2009.878. View

18.

Bennett A, Lesch K, Heils A, Long J, Lorenz J, Shoaf S . Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry. 2002; 7(1):118-22. DOI: 10.1038/sj.mp.4000949. View

19.

Caspi A, McClay J, Moffitt T, Mill J, Martin J, Craig I . Role of genotype in the cycle of violence in maltreated children. Science. 2002; 297(5582):851-4. DOI: 10.1126/science.1072290. View

20.

Nemeroff C, Widerlov E, Bissette G, Walleus H, Karlsson I, Eklund K . Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science. 1984; 226(4680):1342-4. DOI: 10.1126/science.6334362. View