C-acylation of Cyclopropanols: Preparation of Functionalized 1,4-diketones

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2013 Mar 27

PMID 23527827

Citations 13

Authors

Bibhuti Bhusan Parida

Pragna Pratic Das

Mathilde Niocel

Jin Kun Cha

Affiliations

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Abstract

A convenient method for preparing attractively functionalized 1,4-diketones has been devised by palladium-catalyzed cross-coupling of cyclopropanols and acyl chlorides. The utility of this method has been demonstrated in an enantioselective synthesis of (+)-myrmicarin 217.

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