Node-positive Left-sided Breast Cancer: Does VMAT Improve Treatment Plan Quality with Respect to IMRT?

Overview

Journal Strahlenther Onkol

Specialties Oncology
Radiology

Date 2013 Mar 26

PMID 23525513

Citations 23

Authors

M Pasler

D Georg

S Bartelt

J Lutterbach

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of the present work was to explore plan quality and dosimetric accuracy of intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) for lymph node-positive left-sided breast cancer.

Methods: VMAT and IMRT plans were generated with the Pinnacle(3) V9.0 treatment planning system for 10 lymph node-positive left-sided breast cancer patients. VMAT plans were created using a single arc and IMRT was performed with 4 beams using 6, 10, and 15 MV photon energy, respectively. Plans were evaluated both manually and automatically using ArtiView™. Dosimetric plan verification was performed with a 2D ionization chamber array placed in a full scatter phantom.

Results: Photon energy had no significant influence on plan quality for both VMAT and IMRT. Large variability in low doses to the heart was found due to patient anatomy (range V(5 Gy) 26.5-95 %). Slightly more normal tissue dose was found for VMAT (e.g., V(Tissue30%) = 22 %) than in IMRT (V(Tissue30%) = 18 %). The manual and ArtiView™ plan evaluation coincided very accurately for most dose metrics (difference < 1 %). In VMAT, 96.7 % of detector points passed the 3 %/3 mm gamma criterion; marginally better accuracy was found in IMRT (98.3 %).

Conclusion: VMAT for node-positive left-sided breast cancer retains target homogeneity and coverage when compared to IMRT and allows maximum doses to organs at risk to be reduced. ArtiView™ enables fast and accurate plan evaluation.

Citing Articles

Comparative dosimetric and radiobiological assessment of left-sided whole breast and regional nodes with advanced radiotherapy techniques.

Huang Y, Gong C, Luo M, Yuan X, Ding S, Wang X J Radiat Res. 2023; 64(4):677-684.

PMID: 37315943 PMC: 10354844. DOI: 10.1093/jrr/rrad045.

Advancing Precision in Post-mastectomy Chest Wall Radiotherapy: A Comparative Dosimetric Analysis of Volumetric-Modulated Arc Therapy (VMAT) and Intensity-Modulated Radiotherapy (IMRT) Based on Institutional Experience.

Mishra S, Nanda S, Ahirwar M, Simran , M Rath S Cureus. 2023; 15(5):e38464.

PMID: 37276065 PMC: 10235212. DOI: 10.7759/cureus.38464.

A Dosimetric Comparison of Volumetric Modulated Arc Therapy and Intensity Modulated Radiotherapy in Patients Treated with Post-Mastectomy Radiotherapy.

Adeneye S, Akpochafor M, Adedewe N, Habeebu M, Jubril R, Adebayo A Eur J Breast Health. 2023; 19(1):92-98.

PMID: 36605476 PMC: 9806941. DOI: 10.4274/ejbh.galenos.2022.2022-9-2.

Evaluation of Auto-Planning for Left-Side Breast Cancer After Breast-Conserving Surgery Based on Geometrical Relationship.

Li Y, Bai H, Huang D, Chen F, Xia Y Technol Cancer Res Treat. 2021; 20:15330338211033050.

PMID: 34355592 PMC: 8358503. DOI: 10.1177/15330338211033050.

Potential gains: Comparison of a mono-isocentric three-dimensional conformal radiotherapy (3D-CRT) planning technique to hybrid intensity-modulated radiotherapy (hIMRT) to the whole breast and supraclavicular fossa (SCF) region.

Ambrose L, Stanton C, Lewis L, Lamoury G, Morgia M, Carroll S J Med Radiat Sci. 2021; 69(1):75-84.

PMID: 33955205 PMC: 8892437. DOI: 10.1002/jmrs.473.

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