Ketamine: Use in Anesthesia

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2013 Mar 26

PMID 23521979

Citations 52

Authors

Susan Marland

John Ellerton

Gary Andolfatto

Giacomo Strapazzon

Oyvind Thomassen

Brigitta Brandner

Andrew Weatherall

Peter Paal

Affiliations

Soon will be listed here.

Abstract

The role of ketamine anesthesia in the prehospital, emergency department and operating theater settings is not well defined. A nonsystematic review of ketamine was performed by authors from Australia, Europe, and North America. Results were discussed among authors and the final manuscript accepted. Ketamine is a useful agent for induction of anesthesia, procedural sedation, and analgesia. Its properties are appealing in many awkward clinical scenarios. Practitioners need to be cognizant of its side effects and limitations.

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References

Bredmose P, Grier G, Davies G, Lockey D . Pre-hospital use of ketamine in paediatric trauma. Acta Anaesthesiol Scand. 2009; 53(4):543-5. DOI: 10.1111/j.1399-6576.2008.01852.x. View

Ryder S, WAY W, TREVOR A . Comparative pharmacology of the optical isomers of ketamine in mice. Eur J Pharmacol. 1978; 49(1):15-23. DOI: 10.1016/0014-2999(78)90217-0. View

Cook B, GRUBB D, Aldridge L, Doyle E . Comparison of the effects of adrenaline, clonidine and ketamine on the duration of caudal analgesia produced by bupivacaine in children. Br J Anaesth. 1995; 75(6):698-701. DOI: 10.1093/bja/75.6.698. View

Frizelle H, Duranteau J, Samii K . A comparison of propofol with a propofol-ketamine combination for sedation during spinal anesthesia. Anesth Analg. 1997; 84(6):1318-22. DOI: 10.1097/00000539-199706000-00026. View

Weber F, Wulf H, Gruber M, Biallas R . S-ketamine and s-norketamine plasma concentrations after nasal and i.v. administration in anesthetized children. Paediatr Anaesth. 2004; 14(12):983-8. DOI: 10.1111/j.1460-9592.2004.01358.x. View

Panjabi N, Prakash S, Gupta P, Gogia A . Efficacy of three doses of ketamine with bupivacaine for caudal analgesia in pediatric inguinal herniotomy. Reg Anesth Pain Med. 2004; 29(1):28-31. DOI: 10.1016/j.rapm.2003.10.011. View

McGuinness S, Wasiak J, Cleland H, Symons J, Hogan L, Hucker T . A systematic review of ketamine as an analgesic agent in adult burn injuries. Pain Med. 2011; 12(10):1551-8. DOI: 10.1111/j.1526-4637.2011.01220.x. View

Cheong S, Lee K, Lim S, Cho K, Kim M, Ko M . Brief report: the effect of suggestion on unpleasant dreams induced by ketamine administration. Anesth Analg. 2011; 112(5):1082-5. DOI: 10.1213/ANE.0b013e31820eeb0e. View

Grant I, Nimmo W, Clements J . Pharmacokinetics and analgesic effects of i.m. and oral ketamine. Br J Anaesth. 1981; 53(8):805-10. DOI: 10.1093/bja/53.8.805. View

10.

Mulvey J, Qadri A, Maqsood M . Earthquake injuries and the use of ketamine for surgical procedures: the Kashmir experience. Anaesth Intensive Care. 2006; 34(4):489-94. DOI: 10.1177/0310057X0603400413. View

11.

Green S, Hummel C, Wittlake W, Rothrock S, HOPKINS G, Garrett W . What is the optimal dose of intramuscular ketamine for pediatric sedation?. Acad Emerg Med. 1999; 6(1):21-6. DOI: 10.1111/j.1553-2712.1999.tb00089.x. View

12.

Westin B, Walker S, Deumens R, Grafe M, Yaksh T . Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat. Anesthesiology. 2010; 113(1):183-99. PMC: 2902725. DOI: 10.1097/ALN.0b013e3181dcd6ec. View

13.

Aouad M, Moussa A, Dagher C, Muwakkit S, Jabbour-Khoury S, Zbeidy R . Addition of ketamine to propofol for initiation of procedural anesthesia in children reduces propofol consumption and preserves hemodynamic stability. Acta Anaesthesiol Scand. 2008; 52(4):561-5. DOI: 10.1111/j.1399-6576.2008.01584.x. View

14.

Maningas P, Robison M, Mallonee S . The EMS response to the Oklahoma City bombing. Prehosp Disaster Med. 1997; 12(2):80-5. View

15.

Melamed E, Oron Y, Ben-Avraham R, Blumenfeld A, Lin G . The combative multitrauma patient: a protocol for prehospital management. Eur J Emerg Med. 2007; 14(5):265-8. DOI: 10.1097/MEJ.0b013e32823a3c9b. View

16.

Ikeda T, Kazama T, Sessler D, Toriyama S, Niwa K, Shimada C . Induction of anesthesia with ketamine reduces the magnitude of redistribution hypothermia. Anesth Analg. 2001; 93(4):934-8. DOI: 10.1097/00000539-200110000-00027. View

17.

Tsai P, Hsu Y, Lin C, Ko Y, Huang C . Ketamine but not propofol provides additional effects on attenuating sevoflurane-induced emergence agitation in midazolam premedicated pediatric patients. Paediatr Anaesth. 2008; 18(11):1114-5. DOI: 10.1111/j.1460-9592.2008.02593.x. View

18.

Schnabel A, Poepping D, Kranke P, Zahn P, Pogatzki-Zahn E . Efficacy and adverse effects of ketamine as an additive for paediatric caudal anaesthesia: a quantitative systematic review of randomized controlled trials. Br J Anaesth. 2011; 107(4):601-11. DOI: 10.1093/bja/aer258. View

19.

Mort T . Preoxygenation in critically ill patients requiring emergency tracheal intubation. Crit Care Med. 2005; 33(11):2672-5. DOI: 10.1097/01.ccm.0000187131.67594.9e. View

20.

Zempsky W, Cravero J . Relief of pain and anxiety in pediatric patients in emergency medical systems. Pediatrics. 2004; 114(5):1348-56. DOI: 10.1542/peds.2004-1752. View