Current Perspectives on Pathobiology of the Ductus Arteriosus

Overview

Journal J Clin Exp Cardiolog

Publisher Omics Publishing Group

Date 2013 Mar 23

PMID 23519783

Citations 16

Authors

Jason Z Stoller

Sara B DeMauro

John M Dagle

Jeff Reese

Affiliations

Soon will be listed here.

Abstract

The ductus arteriosus (DA) shunts blood away from the lungs during fetal life, but at birth this shunt is no longer needed and the vessel rapidly constricts. Postnatal persistence of the DA, patent ductus arteriosus (PDA), is predominantly a detrimental condition for preterm infants but is simultaneously a condition required to maintain systemic blood flow for infants born with certain severe congenital heart defects. Although PDA in preterm infants is associated with significant morbidities, there is controversy regarding whether PDA is truly causative. Despite advances in our understanding of the pathobiology of PDA, the optimal treatment strategy for PDA in preterm infants is unclear. Here we review recent studies that have continued to elucidate the fundamental mechanisms of DA development and pathogenesis.

Citing Articles

Perinatal Factors Associated with Successful Pharmacologic Closure of the Patent Ductus Arteriosus in Premature Infants.

Sharma P, Gearhart A, Beam K, Spyropoulos F, Powell A, Beam A Pediatr Cardiol. 2024; .

PMID: 39167156 PMC: 11842684. DOI: 10.1007/s00246-024-03626-2.

A novel role for PGE-EP in the developmental programming of the mouse ductus arteriosus: consequences for vessel maturation and function.

Yarboro M, Boatwright N, Sekulich D, Hooper C, Wong T, Poole S Am J Physiol Heart Circ Physiol. 2023; 325(4):H687-H701.

PMID: 37566109 PMC: 10643004. DOI: 10.1152/ajpheart.00294.2023.

Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis.

Gonzalez-Luis G, Borges-Lujan M, Villamor E Front Pediatr. 2023; 11:1078506.

PMID: 36937978 PMC: 10020634. DOI: 10.3389/fped.2023.1078506.

Sex Differences in Patent Ductus Arteriosus Incidence and Response to Pharmacological Treatment in Preterm Infants: A Systematic Review, Meta-Analysis and Meta-Regression.

Borges-Lujan M, Gonzalez-Luis G, Roosen T, Huizing M, Villamor E J Pers Med. 2022; 12(7).

PMID: 35887640 PMC: 9321725. DOI: 10.3390/jpm12071143.

Mouse models of patent ductus arteriosus (PDA) and their relevance for human PDA.

Yarboro M, Gopal S, Su R, Morgan T, Reese J Dev Dyn. 2021; 251(3):424-443.

PMID: 34350653 PMC: 8814064. DOI: 10.1002/dvdy.408.

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