Cyclic Versus Hemi-bastadins. Pleiotropic Anti-cancer Effects: from Apoptosis to Anti-angiogenic and Anti-migratory Effects

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2013 Mar 23

PMID 23519198

Citations 10

Authors

Veronique Mathieu

Nathalie Wauthoz

Florence Lefranc

Hendrik Niemann

Karim Amighi

Robert Kiss

Peter Proksch

Affiliations

Soon will be listed here.

Abstract

Bastadins-6, -9 and -16 isolated from the marine sponge Ianthella basta displayed in vitro cytostatic and/or cytotoxic effects in six human and mouse cancer cell lines. The in vitro growth inhibitory effects of these bastadins were similar in cancer cell lines sensitive to pro-apoptotic stimuli versus cancer cell lines displaying various levels of resistance to pro-apoptotic stimuli. While about ten times less toxic than the natural cyclic bastadins, the synthetically derived 5,5'-dibromohemibastadin-1 (DBHB) displayed not only in vitro growth inhibitory activity in cancer cells but also anti-angiogenic properties. At a concentration of one tenth of its in vitro growth inhibitory concentration, DBHB displayed actual antimigratory effects in mouse B16F10 melanoma cells without any sign of cytotoxicity and/or growth inhibition. The serum concentration used in the cell culture media markedly influenced the DBHB-induced antimigratory effects in the B16F10 melanoma cell population. We are currently developing a specific inhalation formulation for DBHB enabling this compound to avoid plasmatic albumin binding through its direct delivery to the lungs to combat primary as well as secondary (metastases) tumors.

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