Research Progress on the NLRP3 Inflammasome and Its Role in the Central Nervous System

Overview

Journal Neurosci Bull

Specialty Neurology

Date 2013 Mar 21

PMID 23512739

Citations 25

Authors

Shen-Bin Liu

Wen-Li Mi

Yan-Qing Wang

Affiliations

Soon will be listed here.

Abstract

The NLRP3 inflammasome, which consists of the NLRP3 (nucleotide-binding oligomerization domain (Nod)-like receptor 3) scaffold, the ASC (apoptosis-associated speck-like protein containing a CARD) adaptor and procaspase- 1, is assembled after the cytoplasmic LRRs (leucine-rich repeats) of NLRP3 sense pathogens or danger signals. The NLRP3 inflammasome controls the activation of the proteolytic enzyme caspase-1. Caspase-1 in turn regulates the maturation of the proinflammasome cytokines IL-1β and IL-18, which leads to an inflammatory response. The inflammasome plays an important role in the development of Alzheimer's disease and bacterial meningitis, and the NLRP3 inflammasome may become a new target for the prevention and treatment of central nervous system diseases.

Citing Articles

The AGEs/RAGE Signaling Pathway Regulates NLRP3-Mediated Neuronal Pyroptosis After MCAO Injury in Obese Rats.

Zhao L, Li S, Wang X, Zhang L, Zhang J, Liu X J Inflamm Res. 2024; 17:6935-6954.

PMID: 39372588 PMC: 11453143. DOI: 10.2147/JIR.S476458.

NLRP3 Activation Contributes to Memory Impairment in an Experimental Model of Pneumococcal Meningitis.

Generoso J, Faller C, Collodel A, Catalao C, Dominguini D, Petronilho F Mol Neurobiol. 2023; 61(1):239-251.

PMID: 37603152 PMC: 11409915. DOI: 10.1007/s12035-023-03549-8.

Inhibition of the NLRP3 Inflammasome Activation/Assembly through the Activation of the PI3K Pathway by Naloxone Protects Neural Stem Cells from Ischemic Condition.

Kim J, Hwang M, Choi N, Koh S Mol Neurobiol. 2023; 60(9):5330-5342.

PMID: 37300646 DOI: 10.1007/s12035-023-03418-4.

Trends in NLRP3 inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis.

Zhu H, Zhang Y, Feng S, Li Y, Ye Y, Jian Z CNS Neurosci Ther. 2023; 29(10):2940-2954.

PMID: 37088947 PMC: 10493663. DOI: 10.1111/cns.14232.

IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis.

Wang Y, Pei S, Liu Z, Ding Y, Qian T, Wen H Cell Death Dis. 2023; 14(2):103.

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