Therapeutic Approach in the Improvement of Endothelial Dysfunction: the Current State of the Art

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2013 Mar 20

PMID 23509696

Citations 16

Authors

Miroslav Radenkovic

Marko Stojanovic

Tatjana Potpara

Milica Prostran

Affiliations

Soon will be listed here.

Abstract

The endothelium has a central role in the regulation of blood flow through continuous modulation of vascular tone. This is primarily accomplished by balanced release of endothelial relaxing and contractile factors. The healthy endothelial cells are essential for maintenance of vascular homeostasis involving antioxidant, anti-inflammatory, pro-fibrinolytic, anti-adhesive, or anticoagulant effects. Oppositely, endothelial dysfunction is primarily characterized by impaired regulation of vascular tone as a result of reduced endothelial nitric oxide (NO) synthase activity, lack of cofactors for NO synthesis, attenuated NO release, or increased NO degradation. So far, the pharmacological approach in improving/reversal of endothelial dysfunction was shown to be beneficial in clinical trials that have investigated actions of different cardiovascular drugs. The aim of this paper was to summarize some of the latest clinical findings related to therapeutic possibilities for improving endothelial dysfunction in different pathological conditions. In the majority of presented clinical investigations, the assessment of improvement or reversal of endothelial dysfunction was performed through the flow-mediated dilatation measurement, and in some of those endothelial progenitor cells' count was used for the same purpose. Still, given the fast and continuous development of this field, the evidence acquisition included the MEDLINE data base screening and the selection of articles published between 2010 and 2012.

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References

Zankl A, Ivandic B, Andrassy M, Volz H, Krumsdorf U, Blessing E . Telmisartan improves absolute walking distance and endothelial function in patients with peripheral artery disease. Clin Res Cardiol. 2010; 99(12):787-94. DOI: 10.1007/s00392-010-0184-0. View

Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S . Endothelial dysfunction as a target for prevention of cardiovascular disease. Diabetes Care. 2009; 32 Suppl 2:S314-21. PMC: 2811443. DOI: 10.2337/dc09-S330. View

Charakida M, Masi S, Luscher T, Kastelein J, Deanfield J . Assessment of atherosclerosis: the role of flow-mediated dilatation. Eur Heart J. 2010; 31(23):2854-61. DOI: 10.1093/eurheartj/ehq340. View

Fujitaka K, Otani H, Jo F, Jo H, Nomura E, Iwasaki M . Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment. Nutr Res. 2011; 31(11):842-7. DOI: 10.1016/j.nutres.2011.09.028. View

Ma Y, Njike V, Millet J, Dutta S, Doughty K, Treu J . Effects of walnut consumption on endothelial function in type 2 diabetic subjects: a randomized controlled crossover trial. Diabetes Care. 2009; 33(2):227-32. PMC: 2809254. DOI: 10.2337/dc09-1156. View

Lardizabal J, Deedwania P . The anti-ischemic and anti-anginal properties of statins. Curr Atheroscler Rep. 2010; 13(1):43-50. PMC: 3018271. DOI: 10.1007/s11883-010-0147-y. View

Syngle A, Vohra K, Sharma A, Kaur L . Endothelial dysfunction in ankylosing spondylitis improves after tumor necrosis factor-alpha blockade. Clin Rheumatol. 2010; 29(7):763-70. DOI: 10.1007/s10067-010-1402-x. View

Taddei S, Versari D, Cipriano A, Ghiadoni L, Galetta F, Franzoni F . Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients. J Am Coll Cardiol. 2006; 48(3):508-15. DOI: 10.1016/j.jacc.2006.04.074. View

Nagashima H, Endo M . Pitavastatin prevents postprandial endothelial dysfunction via reduction of the serum triglyceride level in obese male subjects. Heart Vessels. 2010; 26(4):428-34. DOI: 10.1007/s00380-010-0071-7. View

10.

Vermeltfoort I, Raijmakers P, Riphagen I, Odekerken D, Kuijper A, Zwijnenburg A . Definitions and incidence of cardiac syndrome X: review and analysis of clinical data. Clin Res Cardiol. 2010; 99(8):475-81. PMC: 2911526. DOI: 10.1007/s00392-010-0159-1. View

11.

Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S . Endothelium-dependent contractions and endothelial dysfunction in human hypertension. Br J Pharmacol. 2009; 157(4):527-36. PMC: 2707964. DOI: 10.1111/j.1476-5381.2009.00240.x. View

12.

Bondonno C, Yang X, Croft K, Considine M, Ward N, Rich L . Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trial. Free Radic Biol Med. 2011; 52(1):95-102. DOI: 10.1016/j.freeradbiomed.2011.09.028. View

13.

Studen K, Sebestjen M, Pfeifer M, Prezelj J . Influence of spironolactone treatment on endothelial function in non-obese women with polycystic ovary syndrome. Eur J Endocrinol. 2010; 164(3):389-95. DOI: 10.1530/EJE-10-0709. View

14.

Radenkovic M, Stojanovic M, Jankovic R, Topalovic M, Stojiljkovic M . Combined contribution of endothelial relaxing autacoides in the rat femoral artery response to CPCA: an adenosine A2 receptor agonist. ScientificWorldJournal. 2012; 2012:143818. PMC: 3349095. DOI: 10.1100/2012/143818. View

15.

Toblli J, DiGennaro F, Giani J, Dominici F . Nebivolol: impact on cardiac and endothelial function and clinical utility. Vasc Health Risk Manag. 2012; 8:151-60. PMC: 3310359. DOI: 10.2147/VHRM.S20669. View

16.

Cubbon R, Kahn M, Wheatcroft S . Effects of insulin resistance on endothelial progenitor cells and vascular repair. Clin Sci (Lond). 2009; 117(5):173-90. DOI: 10.1042/CS20080263. View

17.

Hirata Y, Nagata D, Suzuki E, Nishimatsu H, Suzuki J, Nagai R . Diagnosis and treatment of endothelial dysfunction in cardiovascular disease. Int Heart J. 2010; 51(1):1-6. DOI: 10.1536/ihj.51.1. View

18.

Coppola G, Romano G, Corrado E, Grisanti R, Novo S . Peripheral artery disease: potential role of ACE-inhibitor therapy. Vasc Health Risk Manag. 2009; 4(6):1179-87. PMC: 2663435. DOI: 10.2147/vhrm.s3096. View

19.

Goldstein B, Scalia R, Ma X . Protective vascular and myocardial effects of adiponectin. Nat Clin Pract Cardiovasc Med. 2008; 6(1):27-35. PMC: 2658652. DOI: 10.1038/ncpcardio1398. View

20.

Thijssen D, Black M, Pyke K, Padilla J, Atkinson G, Harris R . Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol. 2010; 300(1):H2-12. PMC: 3023245. DOI: 10.1152/ajpheart.00471.2010. View