Pain Management in Children: Part 2 - A Transition from Codeine to Morphine for Moderate to Severe Pain in Children

Overview

Journal Can Pharm J (Ott)

Specialty Pharmacology

Date 2013 Mar 20

PMID 23509589

Citations 12

Authors

Cecile Wong

Elaine Lau

Lori Palozzi

Fiona Campbell

Affiliations

Soon will be listed here.

Citing Articles

Pain Management in Children Admitted to the Emergency Room: A Narrative Review.

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Pain Evaluation and Treatment in Children: A Practical Approach.

Sansone L, Gentile C, Grasso E, Di Ludovico A, La Bella S, Chiarelli F Children (Basel). 2023; 10(7).

PMID: 37508709 PMC: 10378137. DOI: 10.3390/children10071212.

Opioid Analgesic Prescription in French Children: A National Population-Based Study.

Choufi S, Mounier S, Merlin E, Rochette E, Delorme J, Authier N Int J Environ Res Public Health. 2021; 18(24).

PMID: 34948923 PMC: 8702064. DOI: 10.3390/ijerph182413316.

Update of the Scientific Opinion on opium alkaloids in poppy seeds.

Knutsen H, Alexander J, Barregard L, Bignami M, Bruschweiler B, Ceccatelli S EFSA J. 2020; 16(5):e05243.

PMID: 32625895 PMC: 7009406. DOI: 10.2903/j.efsa.2018.5243.

A European multicentre drug utilisation study of the impact of regulatory measures on prescribing of codeine for pain in children.

Hedenmalm K, Blake K, Donegan K, Macia M, Gil M, Williams J Pharmacoepidemiol Drug Saf. 2019; 28(8):1086-1096.

PMID: 31219227 PMC: 6771637. DOI: 10.1002/pds.4836.

References

Kart T, Christrup L, Rasmussen M . Recommended use of morphine in neonates, infants and children based on a literature review: Part 1--Pharmacokinetics. Paediatr Anaesth. 1997; 7(1):5-11. DOI: 10.1046/j.1460-9592.1997.d01-30.x. View

Ciszkowski C, Madadi P, Phillips M, Lauwers A, Koren G . Codeine, ultrarapid-metabolism genotype, and postoperative death. N Engl J Med. 2009; 361(8):827-8. DOI: 10.1056/NEJMc0904266. View

Duedahl T, Hansen E . A qualitative systematic review of morphine treatment in children with postoperative pain. Paediatr Anaesth. 2007; 17(8):756-74. DOI: 10.1111/j.1460-9592.2007.02213.x. View

Williams D, Hatch D, Howard R . Codeine phosphate in paediatric medicine. Br J Anaesth. 2001; 86(3):413-21. DOI: 10.1093/bja/86.3.413. View

Ali S, Drendel A, Kircher J, Beno S . Pain management of musculoskeletal injuries in children: current state and future directions. Pediatr Emerg Care. 2010; 26(7):518-24. DOI: 10.1097/PEC.0b013e3181e5c02b. View

Koren G, Cairns J, Chitayat D, Gaedigk A, Leeder S . Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet. 2006; 368(9536):704. DOI: 10.1016/S0140-6736(06)69255-6. View

Charney R, Yan Y, Schootman M, Kennedy R, Luhmann J . Oxycodone versus codeine for triage pain in children with suspected forearm fracture: a randomized controlled trial. Pediatr Emerg Care. 2008; 24(9):595-600. DOI: 10.1097/PEC.0b013e3181850ca3. View

Lynn A, Nespeca M, Opheim K, Slattery J . Respiratory effects of intravenous morphine infusions in neonates, infants, and children after cardiac surgery. Anesth Analg. 1993; 77(4):695-701. DOI: 10.1213/00000539-199310000-00007. View

Madadi P, Koren G, Cairns J, Chitayat D, Gaedigk A, Leeder J . Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine. Can Fam Physician. 2007; 53(1):33-5. PMC: 1952551. View

10.

Lynn A, Nespeca M, Bratton S, Shen D . Intravenous morphine in postoperative infants: intermittent bolus dosing versus targeted continuous infusions. Pain. 2000; 88(1):89-95. DOI: 10.1016/S0304-3959(00)00313-4. View

11.

Kelly L, Rieder M, van den Anker J, Malkin B, Ross C, Neely M . More codeine fatalities after tonsillectomy in North American children. Pediatrics. 2012; 129(5):e1343-7. DOI: 10.1542/peds.2011-2538. View

12.

Krane E . Delayed respiratory depression in a child after caudal epidural morphine. Anesth Analg. 1988; 67(1):79-82. View

13.

Crews K, Gaedigk A, Dunnenberger H, Klein T, Shen D, Callaghan J . Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clin Pharmacol Ther. 2011; 91(2):321-6. PMC: 3289963. DOI: 10.1038/clpt.2011.287. View

14.

Caraco Y, Sheller J, Wood A . Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects. J Pharmacol Exp Ther. 1999; 290(1):413-22. View

15.

Kart T, Christrup L, Rasmussen M . Recommended use of morphine in neonates, infants and children based on a literature review: Part 2--Clinical use. Paediatr Anaesth. 1997; 7(2):93-101. DOI: 10.1111/j.1460-9592.1997.tb00488.x. View

16.

Gasche Y, Daali Y, Fathi M, Chiappe A, Cottini S, Dayer P . Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Engl J Med. 2004; 351(27):2827-31. DOI: 10.1056/NEJMoa041888. View

17.

Lloyd-Thomas A . Pain management in paediatric patients. Br J Anaesth. 1990; 64(1):85-104. DOI: 10.1093/bja/64.1.85. View

18.

Clark E, Plint A, Correll R, Gaboury I, Passi B . A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics. 2007; 119(3):460-7. DOI: 10.1542/peds.2006-1347. View

19.

Lynn A, Opheim K, Tyler D . Morphine infusion after pediatric cardiac surgery. Crit Care Med. 1984; 12(10):863-6. DOI: 10.1097/00003246-198410000-00005. View

20.

Blackman R, Reynolds J, Shively J . Intrathecal morphine: dosage and efficacy in younger patients for control of postoperative pain following spinal fusion. Orthopedics. 1991; 14(5):555-7. DOI: 10.3928/0147-7447-19910501-09. View