SLC26A4 Mutations in Patients with Moderate to Severe Hearing Loss

Overview

Journal Biochem Genet

Specialty Molecular Biology

Date 2013 Mar 19

PMID 23504402

Citations 8

Authors

Muhammad Riaz Khan

Rasheeda Bashir

Sadaf Naz

Affiliations

Soon will be listed here.

Abstract

Mutations in SLC26A4 cause either syndromic or nonsyndromic hearing loss. We identified a link between hearing loss and DFNB4 in 3 of the 50 families participating in this study. Sequencing analysis revealed two SLC26A4 mutations, p.V239D and p.S57X, in affected members of the 3 families. These mutations have been previously reported in deaf individuals from the subcontinent, all of whom manifested profound deafness. The patients investigated in our study exhibited moderate to severe hearing loss. Our results show that inactivating SLC26A4 mutations that cause profound deafness can also be involved in the etiology of moderate to severe hearing loss. The type of mutation cannot predict the severity of the hearing loss in all cases, and there may be additional epistatic interactions that could modify the phenotype.

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