Newly Identified Roles of PML in Stem Cell Biology

Overview

Journal Front Oncol

Specialty Oncology

Date 2013 Mar 19

PMID 23504288

Citations 5

Authors

Kyoko Ito

Keisuke Ito

Affiliations

Soon will be listed here.

Abstract

It has long been believed that the tumor suppressor promyelocytic leukemia (PML), the core component of the nuclear substructures known as the PML-nuclear bodies, plays a key part in acute PML (APL), as it is first cloned at the breakpoint of the t(15;17) translocation typical of that disease. Research over the past decade, however, has radically changed our view of how this tumor suppressor is regulated, how it can be therapeutically targeted, and how it functions in a number of tissue systems. One noteworthy recent study, for instance, revealed that PML regulates the activation of fatty acid metabolism, and that this metabolic reprograming plays an essential role in cancer biology and stem cell biology through the control it exerts over stem cell fate decisions. These findings sparked exciting new investigations of PML as a critical "rheostat" responsible for fine-tuning tissue homeostasis, and thus created at the intersection of cancer and stem cell biology a new field of study with important therapeutic implications.

Citing Articles

Unraveling the Big Sleep: Molecular Aspects of Stem Cell Dormancy and Hibernation.

Dias I, Bouma H, Henning R Front Physiol. 2021; 12:624950.

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Quiescence Entry, Maintenance, and Exit in Adult Stem Cells.

Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko V Int J Mol Sci. 2019; 20(9).

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Metabolism and the Control of Cell Fate Decisions and Stem Cell Renewal.

Ito K, Ito K Annu Rev Cell Dev Biol. 2016; 32:399-409.

PMID: 27482603 PMC: 5055439. DOI: 10.1146/annurev-cellbio-111315-125134.

Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation.

Hu C, Fan L, Cen P, Chen E, Jiang Z, Li L Int J Mol Sci. 2016; 17(2):253.

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Metabolic requirements for the maintenance of self-renewing stem cells.

Ito K, Suda T Nat Rev Mol Cell Biol. 2014; 15(4):243-56.

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