Adenoviral Infections in Adult Allogeneic Hematopoietic SCT Recipients: a Single Center Experience

Overview

Journal Bone Marrow Transplant

Specialty General Surgery

Date 2013 Mar 19

PMID 23503529

Citations 13

Authors

M Yilmaz

R F Chemaly

X Y Han

P F Thall

P S Fox

J J Tarrand

M J De Lima

C M Hosing

U R Popat

E Shpall

R E Champlin

M H Qazilbash

Affiliations

Soon will be listed here.

Abstract

Disseminated adenoviral infection (AI) is associated with profound immunosuppression and poor outcome after allogeneic hematopoietic SCT (allo-HSCT). A better understanding of AI in allo-HSCT recipients can serve as a basis to develop more effective management strategies. We evaluated all adult patients who received allo-HSCT at MD Anderson Cancer Center between 1999 and 2008. Among the 2879 allo-HSCT patients, 73 (2.5%) were diagnosed with AI. Enteritis (26%) and pneumonia (24%) were the most common clinical manifestations; pneumonia was the most common cause of adenovirus-associated death. A multivariable Bayesian logistic regression showed that when the joint effects of all covariates were accounted for, cord blood transplant, absolute lymphocyte count (ALC) ≤ 200/mm(3) and male gender were associated with a higher probability of disseminated AI. The OS was significantly worse for patients with AI that was disseminated rather than localized (median of 5 months vs median of 28 months, P<0.001) and for patients with ALC ≤ 200/mm(3) (P<0.001). Disseminated AI, in patients who received allo-HSCT, is a significant cause of morbidity and mortality. Strategies for early diagnosis and intervention are essential, especially for high-risk patients.

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