Enhancers: Five Essential Questions

Overview

Journal Nat Rev Genet

Specialty Genetics

Date 2013 Mar 19

PMID 23503198

Citations 279

Authors

Len A Pennacchio

Wendy Bickmore

Ann Dean

Marcelo A Nobrega

Gill Bejerano

Affiliations

Soon will be listed here.

Abstract

It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent researchers in this field look at how much we know already and what needs to be done to answer these questions.

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