A Mechanism of Cadmium Poisoning: the Cross Effect of Calcium and Cadmium in the Calmodulin-dependent System

Overview

Journal Arch Toxicol

Specialty Toxicology

Date 1990 Jan 1

PMID 2350237

Citations 5

Authors

D Sutoo

K Akiyama

S Imamiya

Affiliations

Soon will be listed here.

Abstract

The effects of the intraventricular (IVT) administration of cadmium on the amount of dopamine (DA) in various regions of the mice brain were analyzed immunohistochemically using a microphotometry system. DA levels in the neostriatum and nucleus accumbens were increased by approximately 30% (p less than 0.01) by the IVT administration of CdCl2 (1 mumol/kg). This effect was abolished by the calmodulin antagonist, W-7 (4.2 micrograms/mouse, IVT). The effects of cadmium on DA levels in the brain were very similar to those seen with calcium. Combining these results with our previous finding that calmodulin does not have the ability to distinguish between calcium and cadmium, a mechanism of cadmium poisoning is suggested in which cadmium activates catecholamine synthesizing enzyme and numerous other enzymes through calmodulin-dependent systems, thereby disturbing many functions in the organism.

Citing Articles

Lead acetate versus cadmium sulfate in the modulation of main physiological pathways controlling detrusor muscle contractility in rat.

Taha S, Daabees T, Aly R, Senbel A Saudi Pharm J. 2022; 30(3):306-316.

PMID: 35498220 PMC: 9051969. DOI: 10.1016/j.jsps.2022.01.012.

Metal homeostasis in pathogenic Epsilonproteobacteria: mechanisms of acquisition, efflux, and regulation.

Kelley B, Lu J, Haley K, Gaddy J, Johnson J Metallomics. 2021; 13(1).

PMID: 33570133 PMC: 8043183. DOI: 10.1093/mtomcs/mfaa002.

Dietary cadmium chloride impairs shell biomineralization by disrupting the metabolism of the eggshell gland in laying hens.

Zhu M, Li H, Miao L, Li L, Dong X, Zou X J Anim Sci. 2020; 98(2).

PMID: 31974567 PMC: 7023603. DOI: 10.1093/jas/skaa025.

Characterization and cadmium-resistant gene expression of biofilm-forming marine bacterium Pseudomonas aeruginosa JP-11.

Chakraborty J, Das S Environ Sci Pollut Res Int. 2014; 21(24):14188-201.

PMID: 25056746 DOI: 10.1007/s11356-014-3308-7.

Heavy metals in the brain of long-tailed duck (Clangula hyemalis) wintering in the Pomeranian Bay, Poland.

Kalisinska E, Szuberla U Biol Trace Elem Res. 1996; 55(1-2):191-7.

PMID: 8971366 DOI: 10.1007/BF02784180.

References

Sutoo D, Akiyama K, Geffard M . Central dopamine-synthesis regulation by the calcium-calmodulin-dependent system. Brain Res Bull. 1989; 22(3):565-9. DOI: 10.1016/0361-9230(89)90113-5. View

Martin S, Bayley P . The effects of Ca2+ and Cd2+ on the secondary and tertiary structure of bovine testis calmodulin. A circular-dichroism study. Biochem J. 1986; 238(2):485-90. PMC: 1147160. DOI: 10.1042/bj2380485. View

McRae-Degueurce A, Geffard M . One perfusion mixture for immunocytochemical detection of noradrenaline, dopamine, serotonin and acetylcholine in the same rat brain. Brain Res. 1986; 376(1):217-9. DOI: 10.1016/0006-8993(86)90922-4. View

Sutoo D, Akiyama K, Iimura K . Effect of calmodulin antagonists on calcium and ethanol-induced sleeping time in mice. Pharmacol Biochem Behav. 1985; 23(4):627-31. DOI: 10.1016/0091-3057(85)90428-9. View

Saavedra J, Zivin J . Tyrosine hydroxylase and dopamine-beta-hydroxylase: distribution in discrete areas of the rat limbic system. Brain Res. 1976; 105(3):517-24. DOI: 10.1016/0006-8993(76)90597-7. View

Sutoo D, Akiyama K, Fujii N, Matsushita K . H-NMR studies of calmodulin: the effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) and Ca2+ on conformational changes of calmodulin. Biochim Biophys Acta. 1986; 873(1):156-60. DOI: 10.1016/0167-4838(86)90203-7. View

Sutoo D, Akiyama K, Fujii N, Matsushita K . Divalent cation dependent conformations of brain calmodulin detected by 1H NMR. Jpn J Pharmacol. 1986; 40(1):169-73. DOI: 10.1254/jjp.40.169. View

Geffard M, Buijs R, Seguela P, Pool C, Le Moal M . First demonstration of highly specific and sensitive antibodies against dopamine. Brain Res. 1984; 294(1):161-5. DOI: 10.1016/0006-8993(84)91323-4. View

Kakiuchi S, Yasuda S, Yamazaki R, Teshima Y, Kanda K, Kakiuchi R . Quantitative determinations of calmodulin in the supernatant and particulate fractions of mammalian tissues. J Biochem. 1982; 92(4):1041-8. DOI: 10.1093/oxfordjournals.jbchem.a134019. View

10.

Sutoo D, Akiyama K, Fujii N, Matsushita K . 1H-NMR studies of calmodulin: the character of the calcium binding sites. Jpn J Pharmacol. 1989; 50(2):217-27. DOI: 10.1254/jjp.50.217. View

11.

Clark W, Vivonia C, Baxter C . Accurate freehand injection into the lateral brain ventricle of the conscious mouse. J Appl Physiol. 1968; 25(3):319-21. DOI: 10.1152/jappl.1968.25.3.319. View

12.

Sutoo D, Akiyama K, Maeda I . [The development of a high sensitivity and high linearity fluorescence microphotometry system for distribution analysis of neurotransmitter in the brain]. Nihon Yakurigaku Zasshi. 1988; 91(4):173-80. DOI: 10.1254/fpj.91.173. View

13.

Niewenhuis R, Prozialeck W . Calmodulin inhibitors protect against cadmium-induced testicular damage in mice. Biol Reprod. 1987; 37(1):127-33. DOI: 10.1095/biolreprod37.1.127. View

14.

Perrino B, Chou I . Role of calmodulin in cadmium-induced microtubule disassembly. Cell Biol Int Rep. 1986; 10(7):565-73. DOI: 10.1016/0309-1651(86)90031-7. View

15.

Biber A, Schmid G, Hempel K . Calmodulin content in specific brain areas. Exp Brain Res. 1984; 56(2):323-6. DOI: 10.1007/BF00236287. View

16.

Arranz M, Perez M, Basagoiti I, Katarneh S, Ribas B, CADORNIGA R . [Pharmacokinetics of cadmium-109 in blood and brain structures of the rat]. Rev Esp Fisiol. 1984; 40(3):365-70. View

17.

Egrie J, Campbell J, FLANGAS A, Siegel F . Regional, cellular and subcellular distribution of calcium-activated cyclic nucleotide phosphodiesterase and calcium-dependent regulator in porcine brain. J Neurochem. 1977; 28(6):1207-13. DOI: 10.1111/j.1471-4159.1977.tb12311.x. View

18.

Sutoo D, Akiyama K, Maeda I . The effect of cadmium administration on the biogenic amine distributions and amounts in the mouse brain. Kitasato Arch Exp Med. 1987; 60(4):157-66. View

19.

OCallaghan J, Miller D . Diethyldithiocarbamate increases distribution of cadmium to brain but prevents cadmium-induced neurotoxicity. Brain Res. 1986; 370(2):354-8. DOI: 10.1016/0006-8993(86)90493-2. View

20.

Sutoo D, Akiyama K, Iimura K . The ability of divalent cations to enhance ethanol-induced sleeping time. Alcohol. 1986; 3(1):69-72. DOI: 10.1016/0741-8329(86)90073-x. View