Insulin Therapies: Current and Future Trends at Dawn

Overview

Journal World J Diabetes

Publisher Baishideng Publishing Group

Specialty Endocrinology

Date 2013 Mar 16

PMID 23493823

Citations 10

Authors

Subhashini Yaturu

Affiliations

Soon will be listed here.

Abstract

Insulin is a key player in the control of hyperglycemia for type 1 diabetes patients and selective individuals in patients of type 2 diabetes. Insulin delivery systems that are currently available for the administration of insulin include insulin syringes, insulin infusion pumps, jet injectors and pens. The traditional and most predictable method for the administration of insulin is by subcutaneous injections. The major drawback of current forms of insulin therapy is their invasive nature. To decrease the suffering, the use of supersonic injectors, infusion pumps, sharp needles and pens has been adopted. Such invasive and intensive techniques have spurred the search for alternative, more acceptable methods for administering insulin. Several non-invasive approaches for insulin delivery are being pursued. The newer methods explored include the artificial pancreas with closed-loop system, transdermal insulin, and buccal, oral and pulmonary routes. This review focuses on the new concepts that are being explored for use in future.

Citing Articles

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References

Slama G, Hautecouverture M, Assan R, TCHOBROUTSKY G . One to five days of continuous intravenous insulin infusion on seven diabetic patients. Diabetes. 1974; 23(9):732-8. DOI: 10.2337/diab.23.9.732. View

Mastrototaro J . The MiniMed Continuous Glucose Monitoring System (CGMS). J Pediatr Endocrinol Metab. 2000; 12 Suppl 3:751-8. View

Heinemann L, Hompesch M, Flacke F, Simms P, Pohl R, Albus K . Reduction of postprandial glycemic excursions in patients with type 1 diabetes: a novel human insulin formulation versus a rapid-acting insulin analog and regular human insulin. J Diabetes Sci Technol. 2011; 5(3):681-6. PMC: 3192634. DOI: 10.1177/193229681100500322. View

Venugopalan P, Sapre A, Venkatesan N, Vyas S . Pelleted bioadhesive polymeric nanoparticles for buccal delivery of insulin: preparation and characterization. Pharmazie. 2001; 56(3):217-9. View

Andrews S, Lee J, Choi S, Prausnitz M . Transdermal insulin delivery using microdermabrasion. Pharm Res. 2011; 28(9):2110-8. PMC: 3152630. DOI: 10.1007/s11095-011-0435-4. View

Rao R, Nanda S . Sonophoresis: recent advancements and future trends. J Pharm Pharmacol. 2009; 61(6):689-705. DOI: 10.1211/jpp.61.06.0001. View

Jonassen I, Havelund S, Hoeg-Jensen T, Steensgaard D, Wahlund P, Ribel U . Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin. Pharm Res. 2012; 29(8):2104-14. PMC: 3399081. DOI: 10.1007/s11095-012-0739-z. View

Raskin P, Heller S, Honka M, Chang P, Boss A, Richardson P . Pulmonary function over 2 years in diabetic patients treated with prandial inhaled Technosphere Insulin or usual antidiabetes treatment: a randomized trial. Diabetes Obes Metab. 2011; 14(2):163-73. DOI: 10.1111/j.1463-1326.2011.01500.x. View

Korytkowski M, Niskanen L, Asakura T . FlexPen: addressing issues of confidence and convenience in insulin delivery. Clin Ther. 2006; 27 Suppl B:S89-100. DOI: 10.1016/j.clinthera.2005.11.019. View

10.

Andrews S, Zarnitsyn V, Bondy B, Prausnitz M . Optimization of microdermabrasion for controlled removal of stratum corneum. Int J Pharm. 2011; 407(1-2):95-104. PMC: 3050026. DOI: 10.1016/j.ijpharm.2011.01.034. View

11.

Zarogoulidis P, Papanas N, Kouliatsis G, Spyratos D, Zarogoulidis K, Maltezos E . Inhaled insulin: too soon to be forgotten?. J Aerosol Med Pulm Drug Deliv. 2011; 24(5):213-23. DOI: 10.1089/jamp.2011.0876. View

12.

Baruah M . Insulin pens: the modern delivery devices. J Assoc Physicians India. 2011; 59 Suppl:38-40. View

13.

Danne T, Bolinder J . New insulins and insulin therapy. Int J Clin Pract Suppl. 2011; (170):26-30. DOI: 10.1111/j.1742-1241.2010.02576.x. View

14.

Khedkar A, Iyer H, Anand A, Verma M, Krishnamurthy S, Savale S . A dose range finding study of novel oral insulin (IN-105) under fed conditions in type 2 diabetes mellitus subjects. Diabetes Obes Metab. 2010; 12(8):659-64. DOI: 10.1111/j.1463-1326.2010.01213.x. View

15.

Pan Y, Li Y, Zhao H, Zheng J, Xu H, Wei G . Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm. 2002; 249(1-2):139-47. DOI: 10.1016/s0378-5173(02)00486-6. View

16.

Heinemann L, Nosek L, Flacke F, Albus K, Krasner A, Pichotta P . U-100, pH-Neutral formulation of VIAject(®) : faster onset of action than insulin lispro in patients with type 1 diabetes. Diabetes Obes Metab. 2011; 14(3):222-7. DOI: 10.1111/j.1463-1326.2011.01516.x. View

17.

Sung H, Sonaje K, Feng S . Nanomedicine for diabetes treatment. Nanomedicine (Lond). 2011; 6(8):1297-300. DOI: 10.2217/nnm.11.124. View

18.

Ramachandran R, Paul W, Sharma C . Synthesis and characterization of PEGylated calcium phosphate nanoparticles for oral insulin delivery. J Biomed Mater Res B Appl Biomater. 2008; 88(1):41-8. DOI: 10.1002/jbm.b.31241. View

19.

Batheja P, Priya B, Thakur R, Rashmi T, Michniak B, Bozena M . Transdermal iontophoresis. Expert Opin Drug Deliv. 2005; 3(1):127-38. DOI: 10.1517/17425247.3.1.127. View

20.

Cui F, Qian F, Zhao Z, Yin L, Tang C, Yin C . Preparation, characterization, and oral delivery of insulin loaded carboxylated chitosan grafted poly(methyl methacrylate) nanoparticles. Biomacromolecules. 2009; 10(5):1253-8. DOI: 10.1021/bm900035u. View