Influence of Maternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Socioemotional Behaviors in Offspring Rats

Overview

Journal Environ Health Insights

Publisher Sage Publications

Specialty Environmental Health

Date 2013 Mar 16

PMID 23493046

Citations 6

Authors

Anh T N Nguyen

Muneko Nishijo

Etsuro Hori

Nui M Nguyen

Tai T Pham

Kohji Fukunaga

Hideaki Nakagawa

Anh H Tran

Hisao Nishijo

Affiliations

Soon will be listed here.

Abstract

Effects of dioxins on cognitive functions were reported in previous studies conducted in humans and animals. In the present study, we investigated the influence of dioxin exposure during pregnancy on social interaction and on the activity of offspring, which are related to neurodevelopmental disturbances. In addition, we analyzed neurochemical alterations of the limbic system of rat brains to suggest one mechanism of dioxin effects on brain function. We believe that this manuscript is suitable for publication in "Environmental Health Insights" because it provides an interesting topic for a wide global audience. To clarify the relationships between maternal dioxin exposure and socioemotional functions of rat offspring, dams were given TCDD (1.0 μg/kg) on gestational day 15. Social interactions and forced swimming time were compared between TCDD-exposed and control offspring in each gender. Frequency and duration of locomotion were higher, and durations per one behavior of proximity and social contact were significantly lower in the exposed males, while only the duration of proximity was lower in the exposed females. Forced swimming time on the first day was significantly longer in the exposed males. In the limbic system of the rat brain, the levels and/or activity of CaMKIIα were decreased in males and were increased in females in the exposed offspring. These results suggest that prenatal TCDD exposure induces hyperactivity and socioemotional deficits, particularly in the male offspring due to alterations in CaMKIIα activity in the limbic system of the brain.

Citing Articles

Effects of Low-Dose Gestational TCDD Exposure on Behavior and on Hippocampal Neuron Morphology and Gene Expression in Mice.

Gileadi T, Swamy A, Hore Z, Horswell S, Ellegood J, Mohan C Environ Health Perspect. 2021; 129(5):57002.

PMID: 33956508 PMC: 8101924. DOI: 10.1289/EHP7352.

Prenatal dioxin exposure and neuropsychological functioning in the Seveso Second Generation Health Study.

Ames J, Warner M, Siracusa C, Signorini S, Brambilla P, Mocarelli P Int J Hyg Environ Health. 2019; 222(3):425-433.

PMID: 30638868 PMC: 6440851. DOI: 10.1016/j.ijheh.2018.12.009.

Sex-specific effects of perinatal dioxin exposure on eating behavior in 3-year-old Vietnamese children.

Nguyen A, Nishijo M, Pham T, Tran N, Tran A, Hoang L BMC Pediatr. 2018; 18(1):213.

PMID: 29976197 PMC: 6034299. DOI: 10.1186/s12887-018-1171-2.

Impacts of Perinatal Dioxin Exposure on Motor Coordination and Higher Cognitive Development in Vietnamese Preschool Children: A Five-Year Follow-Up.

Tran N, Pham T, Ozawa K, Nishijo M, Nguyen A, Tran T PLoS One. 2016; 11(1):e0147655.

PMID: 26824471 PMC: 4732982. DOI: 10.1371/journal.pone.0147655.

Delayed effects of developmental exposure to low levels of the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB126) on adult zebrafish behavior.

Glazer L, Hahn M, Aluru N Neurotoxicology. 2015; 52:134-43.

PMID: 26616910 PMC: 4753093. DOI: 10.1016/j.neuro.2015.11.012.

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