CancerDR: Cancer Drug Resistance Database

Overview

Journal Sci Rep

Specialty Science

Date 2013 Mar 15

PMID 23486013

Citations 51

Authors

Rahul Kumar

Kumardeep Chaudhary

Sudheer Gupta

Harinder Singh

Shailesh Kumar

Ankur Gautam

Pallavi Kapoor

Gajendra P S Raghava

Affiliations

Soon will be listed here.

Abstract

Cancer therapies are limited by the development of drug resistance, and mutations in drug targets is one of the main reasons for developing acquired resistance. The adequate knowledge of these mutations in drug targets would help to design effective personalized therapies. Keeping this in mind, we have developed a database "CancerDR", which provides information of 148 anti-cancer drugs, and their pharmacological profiling across 952 cancer cell lines. CancerDR provides comprehensive information about each drug target that includes; (i) sequence of natural variants, (ii) mutations, (iii) tertiary structure, and (iv) alignment profile of mutants/variants. A number of web-based tools have been integrated in CancerDR. This database will be very useful for identification of genetic alterations in genes encoding drug targets, and in turn the residues responsible for drug resistance. CancerDR allows user to identify promiscuous drug molecules that can kill wide range of cancer cells. CancerDR is freely accessible at http://crdd.osdd.net/raghava/cancerdr/

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