Creation of Resveratrol-enriched Rice for the Treatment of Metabolic Syndrome and Related Diseases

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Mar 14

PMID 23483945

Citations 28

Authors

So-Hyeon Baek

Woon-Chul Shin

Hak-Seung Ryu

Dae-Woo Lee

Eunjung Moon

Chun-Sun Seo

Eunson Hwang

Hyun-Seo Lee

Mi-Hyun Ahn

Youngju Jeon

Hyeon-Jung Kang

Sang-Won Lee

Sun Yeou Kim

Roshan DSouza

Hyeon-Jin Kim

Seong-Tshool Hong

Jong-Seong Jeon

Affiliations

Soon will be listed here.

Abstract

Resveratrol has been clinically shown to possess a number of human health benefits. As a result, many attempts have been made to engineer resveratrol production in major cereal grains but have been largely unsuccessful. In this study, we report the creation of a transgenic rice plant that accumulates 1.9 µg resveratrol/g in its grain, surpassing the previously reported anti-metabolic syndrome activity of resveratrol through a synergistic interaction between the transgenic resveratrol and the endogenous properties of the rice. Consumption of our transgenic resveratrol-enriched rice significantly improved all aspects of metabolic syndrome and related diseases in animals fed a high-fat diet. Compared with the control animals, the resveratrol-enriched rice reduced body weight, blood glucose, triglycerides, total cholesterol, and LDL-cholesterol by 24.7%, 22%, 37.4%, 27%, and 59.6%, respectively. The resveratrol-enriched rice from our study may thus provide a safe and convenient means of preventing metabolic syndrome and related diseases without major lifestyle changes or the need for daily medications. These results also suggest that future transgenic plants could be improved if the synergistic interactions of the transgene with endogenous traits of the plant are considered in the experimental design.

Citing Articles

Coinhibitory Effects of Resveratrol- and Protopanaxadiol-Enriched Rice Seed Extracts Against Melanogenic Activities in Melan-a Cells.

Monmai C, Kuk Y, Baek S Plants (Basel). 2024; 13(23).

PMID: 39683178 PMC: 11644661. DOI: 10.3390/plants13233385.

Anti-Inflammatory Effects of the Combined Treatment of Resveratrol- and Protopanaxadiol-Enriched Rice Seed Extract on Lipopolysaccharide-Stimulated RAW264.7 Cells.

Monmai C, Baek S Molecules. 2024; 29(18).

PMID: 39339339 PMC: 11434488. DOI: 10.3390/molecules29184343.

Resveratrol-Enriched Rice Callus Extract Inhibits Oxidative and Cellular Melanogenic Activities in Melan-A Cells.

Monmai C, Kim J, Baek S Antioxidants (Basel). 2024; 13(6).

PMID: 38929064 PMC: 11201182. DOI: 10.3390/antiox13060625.

Natural Products in the Clinical Management of Metabolic Syndrome.

Tabatabaei-Malazy O, Lavari N, Abdollahi M Handb Exp Pharmacol. 2024; 287():123-157.

PMID: 38418667 DOI: 10.1007/164_2024_711.

Germinated Rice Seeds Improved Resveratrol Production to Suppress Adipogenic and Inflammatory Molecules in 3T3-L1 Adipocytes.

Monmai C, Kim J, Baek S Molecules. 2023; 28(15).

PMID: 37570719 PMC: 10420918. DOI: 10.3390/molecules28155750.

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