The Diagnosis and Management of Giant Cell Lesions of the Jaws

Overview

Journal Ann Maxillofac Surg

Date 2013 Mar 14

PMID 23482697

Citations 14

Authors

Anthony M Pogrel

Affiliations

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Abstract

This article will review current thoughts with regard to the etiology, histopathology, diagnosis, and management of giant cell lesions of the jaws. It will attempt to point out the differences between these lesions and giant cell lesions elsewhere in the body and also the current techniques for medical management of these conditions including steroid injections, calcitonin treatment, and alpha interferon treatment.

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References

Roberts J, Shores C, Rose A . Surgical treatment is warranted in aggressive central giant cell granuloma: a report of 2 cases. Ear Nose Throat J. 2009; 88(3):E8-E13. View

Eckardt A, Pogrel M, Kaban L, Chew K, MAYALL B . Central giant cell granulomas of the jaws. Nuclear DNA analysis using image cytometry. Int J Oral Maxillofac Surg. 1989; 18(1):3-6. DOI: 10.1016/s0901-5027(89)80004-9. View

Pogrel M . Calcitonin therapy for central giant cell granuloma. J Oral Maxillofac Surg. 2003; 61(6):649-53; discussion 53-4. DOI: 10.1053/joms.2003.50129. View

JAFFE H . Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-oseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol. 1953; 6(1):159-75. DOI: 10.1016/0030-4220(53)90151-0. View

Kaban L, Troulis M, Wilkinson M, Wilkinson M, Ebb D, Dodson T . Adjuvant antiangiogenic therapy for giant cell tumors of the jaws. J Oral Maxillofac Surg. 2007; 65(10):2018-24. DOI: 10.1016/j.joms.2007.03.030. View

de Lange J, Van Den Akker H, van den Berg H, Richel D, Gortzak R . Limited regression of central giant cell granuloma by interferon alpha after failed calcitonin therapy: a report of 2 cases. Int J Oral Maxillofac Surg. 2006; 35(9):865-9. DOI: 10.1016/j.ijom.2006.02.011. View

Imai Y, Kanno K, Moriya T, Kayano S, Seino H, Matsubara Y . A missense mutation in the SH3BP2 gene on chromosome 4p16.3 found in a case of nonfamilial cherubism. Cleft Palate Craniofac J. 2003; 40(6):632-8. DOI: 10.1597/1545-1569_2003_040_0632_ammits_2.0.co_2. View

Flanagan A, Nui B, Tinkler S, Horton M, Williams D, Chambers T . The multinucleate cells in giant cell granulomas of the jaw are osteoclasts. Cancer. 1988; 62(6):1139-45. DOI: 10.1002/1097-0142(19880915)62:6<1139::aid-cncr2820620617>3.0.co;2-8. View

Hernandez G, Lopez-Pintor R, Torres J, de Vicente J . Clinical outcomes of peri-implant peripheral giant cell granuloma: a report of three cases. J Periodontol. 2009; 80(7):1184-91. DOI: 10.1902/jop.2009.090081. View

10.

Chuong R, Kaban L, Kozakewich H . Central giant cell lesions of the jaws: a clinicopathologic study. J Oral Maxillofac Surg. 1986; 44(9):708-13. DOI: 10.1016/0278-2391(86)90040-6. View

11.

Tiziani V, Reichenberger E, Buzzo C, Niazi S, Fukai N, Stiller M . The gene for cherubism maps to chromosome 4p16. Am J Hum Genet. 1999; 65(1):158-66. PMC: 1378086. DOI: 10.1086/302456. View

12.

Kermer C, Millesi W, Watzke I . Local injection of corticosteroids for central giant cell granuloma. A case report. Int J Oral Maxillofac Surg. 1994; 23(6 Pt 1):366-8. DOI: 10.1016/s0901-5027(05)80057-8. View

13.

Carlos R, Sedano H . Intralesional corticosteroids as an alternative treatment for central giant cell granuloma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002; 93(2):161-6. DOI: 10.1067/moe.2002.119971. View

14.

Lo B, Faiyaz-Ul-Haque M, Kennedy S, Aviv R, Tsui L, Teebi A . Novel mutation in the gene encoding c-Abl-binding protein SH3BP2 causes cherubism. Am J Med Genet A. 2003; 121A(1):37-40. DOI: 10.1002/ajmg.a.20226. View

15.

ORegan E, Gibb D, Odell E . Rapid growth of giant cell granuloma in pregnancy treated with calcitonin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 92(5):532-8. DOI: 10.1067/moe.2001.119246. View

16.

de Lange J, Rosenberg A, Van Den Akker H, Koole R, Wirds J, van den Berg H . Treatment of central giant cell granuloma of the jaw with calcitonin. Int J Oral Maxillofac Surg. 1999; 28(5):372-6. DOI: 10.1034/j.1399-0020.1999.285280513.x. View

17.

Bernier J, CAHN L . The peripheral giant cell reparative granuloma. J Am Dent Assoc. 1954; 49(2):141-8. DOI: 10.14219/jada.archive.1954.0138. View

18.

Ficarra G, Kaban L, Hansen L . Central giant cell lesions of the mandible and maxilla: a clinicopathologic and cytometric study. Oral Surg Oral Med Oral Pathol. 1987; 64(1):44-9. DOI: 10.1016/0030-4220(87)90115-0. View

19.

Mangion J, Rahman N, Edkins S, Barfoot R, Nguyen T, Sigurdsson A . The gene for cherubism maps to chromosome 4p16.3. Am J Hum Genet. 1999; 65(1):151-7. PMC: 1378085. DOI: 10.1086/302454. View

20.

Allon D, Anavi Y, Calderon S . Central giant cell lesion of the jaw: nonsurgical treatment with calcitonin nasal spray. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 107(6):811-8. DOI: 10.1016/j.tripleo.2009.02.013. View