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NK Cell-released Exosomes: Natural Nanobullets Against Tumors

Overview
Journal Oncoimmunology
Specialty Allergy & Immunology
Date 2013 Mar 14
PMID 23482694
Citations 50
Authors
Stefano Fais
Affiliations
Soon will be listed here.
Abstract

We have recently reported that human natural killer (NK) cells release exosomes that express both NK-cell markers and cytotoxic molecules. Similar results were obtained with circulating exosomes from human healthy donors. Both NK-cell derived and circulating exosomes exerted a full functional activity and killed both tumor and activated immune cells. These findings indicate that NK-cell derived exosomes might constitute a new promising therapeutic tool.

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