AMPAR Trafficking in Synapse Maturation and Plasticity

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2013 Mar 12

PMID 23475111

Citations 36

Authors

Silvia Bassani

Alessandra Folci

Jonathan Zapata

Maria Passafaro

Affiliations

Soon will be listed here.

Abstract

Glutamate ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (AMPARs) mediate most fast excitatory synaptic transmission in the central nervous system. The content and composition of AMPARs in postsynaptic membranes (which determine synaptic strength) are dependent on the regulated trafficking of AMPAR subunits in and out of the membranes. AMPAR trafficking is a key mechanism that drives nascent synapse development, and is the main determinant of both Hebbian and homeostatic plasticity in mature synapses. Hebbian plasticity seems to be the biological substrate of at least some forms of learning and memory; while homeostatic plasticity (also known as synaptic scaling) keeps neuronal circuits stable by maintaining changes within a physiological range. In this review, we examine recent findings that provide further understanding of the role of AMPAR trafficking in synapse maturation, Hebbian plasticity, and homeostatic plasticity.

Citing Articles

Female mice lacking GluA3 show early onset of hearing loss, cochlear synaptopathy, and afferent terminal swellings in ambient sound levels.

Pal I, Bhattacharyya A, V-Ghaffari B, Williams E, Xiao M, Rutherford M iScience. 2025; 28(2):111799.

PMID: 39935454 PMC: 11810710. DOI: 10.1016/j.isci.2025.111799.

Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation.

Lim C, Ogawa S, Kumari Y Arch Pharm Res. 2024; 48(1):1-42.

PMID: 39653971 DOI: 10.1007/s12272-024-01523-z.

Female GluA3-KO mice show early onset hearing loss and afferent swellings in ambient sound levels.

Pal I, Bhattacharyya A, V-Ghaffari B, Williams E, Xiao M, Rutherford M bioRxiv. 2024; .

PMID: 38659964 PMC: 11042237. DOI: 10.1101/2024.02.21.581467.

Extracellular Vesicles in the Central Nervous System: A Novel Mechanism of Neuronal Cell Communication.

Filannino F, Panaro M, Benameur T, Pizzolorusso I, Porro C Int J Mol Sci. 2024; 25(3).

PMID: 38338906 PMC: 10855168. DOI: 10.3390/ijms25031629.

Palamarchuk I, Slavich G, Vaillancourt T, Rajji T BMC Neurosci. 2023; 24(1):65.

PMID: 38087196 PMC: 10714507. DOI: 10.1186/s12868-023-00831-2.

References

Plant K, Pelkey K, Bortolotto Z, Morita D, Terashima A, McBain C . Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation. Nat Neurosci. 2006; 9(5):602-4. DOI: 10.1038/nn1678. View

Sheng M . The postsynaptic NMDA-receptor--PSD-95 signaling complex in excitatory synapses of the brain. J Cell Sci. 2001; 114(Pt 7):1251. DOI: 10.1242/jcs.114.7.1251. View

Squire L, Barondes S . Memory impairment during prolonged training in mice given inhibitors of cerebral protein synthesis. Brain Res. 1973; 56:215-25. DOI: 10.1016/0006-8993(73)90336-3. View

Monyer H, Seeburg P, Wisden W . Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing. Neuron. 1991; 6(5):799-810. DOI: 10.1016/0896-6273(91)90176-z. View

Lu W, Man H, Ju W, Trimble W, MacDonald J, Wang Y . Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. Neuron. 2001; 29(1):243-54. DOI: 10.1016/s0896-6273(01)00194-5. View

Noel J, Ralph G, Pickard L, Williams J, Molnar E, Uney J . Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron. 1999; 23(2):365-76. DOI: 10.1016/s0896-6273(00)80786-2. View

Guire E, Oh M, Soderling T, Derkach V . Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I. J Neurosci. 2008; 28(23):6000-9. PMC: 2671029. DOI: 10.1523/JNEUROSCI.0384-08.2008. View

Danielson E, Zhang N, Metallo J, Kaleka K, Shin S, Gerges N . S-SCAM/MAGI-2 is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors. J Neurosci. 2012; 32(20):6967-80. PMC: 3365591. DOI: 10.1523/JNEUROSCI.0025-12.2012. View

Thiagarajan T, Piedras-Renteria E, Tsien R . alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength. Neuron. 2002; 36(6):1103-14. DOI: 10.1016/s0896-6273(02)01049-8. View

10.

Hall B, Ghosh A . Regulation of AMPA receptor recruitment at developing synapses. Trends Neurosci. 2008; 31(2):82-9. DOI: 10.1016/j.tins.2007.11.010. View

11.

Kessels H, Kopec C, Klein M, Malinow R . Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution. Nat Neurosci. 2009; 12(7):888-96. PMC: 3922706. DOI: 10.1038/nn.2340. View

12.

Feldmeyer D, Kask K, Brusa R, Kornau H, Kolhekar R, Rozov A . Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B. Nat Neurosci. 1999; 2(1):57-64. DOI: 10.1038/4561. View

13.

Hanley J, Henley J . PICK1 is a calcium-sensor for NMDA-induced AMPA receptor trafficking. EMBO J. 2005; 24(18):3266-78. PMC: 1224691. DOI: 10.1038/sj.emboj.7600801. View

14.

Hynes R, Lively J, McCarty J, Taverna D, Francis S, Hodivala-Dilke K . The diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harb Symp Quant Biol. 2003; 67:143-53. DOI: 10.1101/sqb.2002.67.143. View

15.

Malenka R, Bear M . LTP and LTD: an embarrassment of riches. Neuron. 2004; 44(1):5-21. DOI: 10.1016/j.neuron.2004.09.012. View

16.

Bowie D, Mayer M . Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block. Neuron. 1995; 15(2):453-62. DOI: 10.1016/0896-6273(95)90049-7. View

17.

Wyszynski M, Kim E, Dunah A, Passafaro M, Valtschanoff J, Serra-Pages C . Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. Neuron. 2002; 34(1):39-52. DOI: 10.1016/s0896-6273(02)00640-2. View

18.

Shen L, Liang F, Walensky L, Huganir R . Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association. J Neurosci. 2000; 20(21):7932-40. PMC: 6772741. View

19.

He P, Liu Q, Wu J, Shen Y . Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons. FASEB J. 2011; 26(1):334-45. PMC: 3250242. DOI: 10.1096/fj.11-192716. View

20.

Keifer J, Zheng Z . AMPA receptor trafficking and learning. Eur J Neurosci. 2010; 32(2):269-77. PMC: 3985283. DOI: 10.1111/j.1460-9568.2010.07339.x. View