Towards Theranostic Multicompartment Microcapsules: In-situ Diagnostics and Laser-induced Treatment

Overview

Journal Theranostics

Date 2013 Mar 9

PMID 23471141

Citations 12

Authors

Ranhua Xiong

Stefaan J Soenen

Kevin Braeckmans

Andre G Skirtach

Affiliations

Soon will be listed here.

Abstract

Paving the way towards the application of polyelectrolyte multilayer capsules in theranostics, we describe diagnostic multi-functionality and drug delivery using multicompartment polymeric capsules which represent the next generation of drug delivery carriers. Their versatility is particularly important for potential applications in the area of theranostics wherein the carriers are endowed with the functionality for both diagnostics and therapy. Responsiveness towards external stimuli is attractive for providing controlled and on-demand release of encapsulated materials. An overview of external stimuli is presented with an emphasis on light as a physical stimulus which has been widely used for activation of microcapsules and release of their contents. In this article we also describe existing and new approaches to build multicompartment microcapsules as well as means available to achieve controlled and triggered release from their subcompartments, with a focus on applications in theranostics. Outlook for future directions in the area are highlighted.

Citing Articles

Immunogenic Cell Death and Role of Nanomaterials Serving as Therapeutic Vaccine for Personalized Cancer Immunotherapy.

Catanzaro E, Feron O, Skirtach A, Krysko D Front Immunol. 2022; 13:925290.

PMID: 35844506 PMC: 9280641. DOI: 10.3389/fimmu.2022.925290.

Biodegradable polyelectrolyte/magnetite capsules for MR imaging and magnetic targeting of tumors.

Svenskaya Y, Garello F, Lengert E, Kozlova A, Verkhovskii R, Bitonto V Nanotheranostics. 2021; 5(3):362-377.

PMID: 33850694 PMC: 8040826. DOI: 10.7150/ntno.59458.

Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering.

Kastania G, Campbell J, Mitford J, Volodkin D Micromachines (Basel). 2020; 11(9).

PMID: 32842692 PMC: 7570195. DOI: 10.3390/mi11090797.

Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near-infrared light mediated cancer therapy.

Prasad R, Jain N, Yadav A, Chauhan D, Devrukhkar J, Kumawat M Commun Biol. 2020; 3(1):284.

PMID: 32504032 PMC: 7275035. DOI: 10.1038/s42003-020-1016-z.

Trojan-Horse-Like Stimuli-Responsive Microcapsules.

Mou C, Wang W, Li Z, Ju X, Xie R, Deng N Adv Sci (Weinh). 2018; 5(6):1700960.

PMID: 29938173 PMC: 6010793. DOI: 10.1002/advs.201700960.

References

Palankar R, Skirtach A, Kreft O, Bedard M, Garstka M, Gould K . Controlled intracellular release of peptides from microcapsules enhances antigen presentation on MHC class I molecules. Small. 2009; 5(19):2168-76. DOI: 10.1002/smll.200900809. View

Marguet M, Bonduelle C, Lecommandoux S . Multicompartmentalized polymeric systems: towards biomimetic cellular structure and function. Chem Soc Rev. 2012; 42(2):512-29. DOI: 10.1039/c2cs35312a. View

Jiang S, Chen Q, Tripathy M, Luijten E, Schweizer K, Granick S . Janus particle synthesis and assembly. Adv Mater. 2010; 22(10):1060-71. DOI: 10.1002/adma.200904094. View

Gao L, Fei J, Zhao J, Li H, Cui Y, Li J . Hypocrellin-loaded gold nanocages with high two-photon efficiency for photothermal/photodynamic cancer therapy in vitro. ACS Nano. 2012; 6(9):8030-40. DOI: 10.1021/nn302634m. View

Kolesnikova T, Skirtach A, Mohwald H . Red blood cells and polyelectrolyte multilayer capsules: natural carriers versus polymer-based drug delivery vehicles. Expert Opin Drug Deliv. 2012; 10(1):47-58. DOI: 10.1517/17425247.2013.730516. View

Chow A, Tong H, Chattopadhyay P, Shekunov B . Particle engineering for pulmonary drug delivery. Pharm Res. 2007; 24(3):411-37. DOI: 10.1007/s11095-006-9174-3. View

Tong R, Kohane D . Shedding light on nanomedicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012; 4(6):638-62. PMC: 3474862. DOI: 10.1002/wnan.1188. View

Skorb E, Skirtach A, Sviridov D, Shchukin D, Mohwald H . Laser-controllable coatings for corrosion protection. ACS Nano. 2009; 3(7):1753-60. DOI: 10.1021/nn900347x. View

Cayre O, Paunov V, Velev O . Fabrication of dipolar colloid particles by microcontact printing. Chem Commun (Camb). 2003; (18):2296-7. DOI: 10.1039/b307296g. View

10.

Leung S, Romanowski M . Light-activated content release from liposomes. Theranostics. 2012; 2(10):1020-36. PMC: 3493200. DOI: 10.7150/thno.4847. View

11.

Ling X, Phang I, Acikgoz C, Yilmaz M, Hempenius M, Vancso G . Janus particles with controllable patchiness and their chemical functionalization and supramolecular assembly. Angew Chem Int Ed Engl. 2009; 48(41):7677-82. DOI: 10.1002/anie.200903579. View

12.

Volodkin D, Delcea M, Mohwald H, Skirtach A . Remote near-IR light activation of a hyaluronic acid/poly(l-lysine) multilayered film and film-entrapped microcapsules. ACS Appl Mater Interfaces. 2010; 1(8):1705-10. DOI: 10.1021/am900269c. View

13.

Kreft O, Prevot M, Mohwald H, Sukhorukov G . Shell-in-shell microcapsules: a novel tool for integrated, spatially confined enzymatic reactions. Angew Chem Int Ed Engl. 2007; 46(29):5605-8. DOI: 10.1002/anie.200701173. View

14.

Delcea M, Sternberg N, Yashchenok A, Georgieva R, Baumler H, Mohwald H . Nanoplasmonics for dual-molecule release through nanopores in the membrane of red blood cells. ACS Nano. 2012; 6(5):4169-80. DOI: 10.1021/nn3006619. View

15.

Alessandri I, Depero L . Using plasmonic heating of gold nanoparticles to generate local SER(R)S-active TiO2 spots. Chem Commun (Camb). 2009; (17):2359-61. DOI: 10.1039/b900647h. View

16.

Amstad E, Reimhult E . Nanoparticle actuated hollow drug delivery vehicles. Nanomedicine (Lond). 2011; 7(1):145-64. DOI: 10.2217/nnm.11.167. View

17.

Kohler D, Madaboosi N, Delcea M, Schmidt S, De Geest B, Volodkin D . Patchiness of embedded particles and film stiffness control through concentration of gold nanoparticles. Adv Mater. 2012; 24(8):1095-100. DOI: 10.1002/adma.201103958. View

18.

Kazakova L, Shabarchina L, Anastasova S, Pavlov A, Vadgama P, Skirtach A . Chemosensors and biosensors based on polyelectrolyte microcapsules containing fluorescent dyes and enzymes. Anal Bioanal Chem. 2012; 405(5):1559-68. DOI: 10.1007/s00216-012-6381-0. View

19.

Delcea M, Mohwald H, Skirtach A . Stimuli-responsive LbL capsules and nanoshells for drug delivery. Adv Drug Deliv Rev. 2011; 63(9):730-47. DOI: 10.1016/j.addr.2011.03.010. View

20.

Lukianova-Hleb E, Samaniego A, Wen J, Metelitsa L, Chang C, Lapotko D . Selective gene transfection of individual cells in vitro with plasmonic nanobubbles. J Control Release. 2011; 152(2):286-93. PMC: 3113639. DOI: 10.1016/j.jconrel.2011.02.006. View