The Emerging Role of Acetylation in the Regulation of Autophagy

Overview

Journal Autophagy

Specialty Cell Biology

Date 2013 Mar 8

PMID 23466676

Citations 96

Authors

Agnes Banreti

Miklos Sass

Yacine Graba

Affiliations

Soon will be listed here.

Abstract

Autophagy is an evolutionarily conserved catabolic process through which different components of the cells are sequestered into double-membrane cytosolic vesicles called autophagosomes, and fated to degradation through fusion with lysosomes. Autophagy plays a major function in many physiological processes including response to different stress factors, energy homeostasis, elimination of cellular organelles and tissue remodeling during development. Consequently, autophagy is strictly controlled and post-translational modifications such as phosphorylation and ubiquitination have long been associated with autophagy regulation. In contrast, the importance of acetylation in autophagy control has only emerged in the last few years. In this review, we summarize how previously identified histone acetylases and deacetylases modify key autophagic effector proteins, and discuss how this has an impact on physiological and pathological cellular processes.

Citing Articles

The role of autophagy in fibrosis: Mechanisms, progression and therapeutic potential (Review).

Chen Y, Wang Z, Ma Q, Sun C Int J Mol Med. 2025; 55(4).

PMID: 39950330 PMC: 11878481. DOI: 10.3892/ijmm.2025.5502.

Acetylation modification in the regulation of macroautophagy.

Huang L, Guo H Adv Biotechnol (Singap). 2025; 2(2):19.

PMID: 39883319 PMC: 11740868. DOI: 10.1007/s44307-024-00027-7.

Protein modification regulated autophagy in and .

Wu W, Lin L, Zhao Y, Li H, Zhang R Front Physiol. 2023; 14:1281555.

PMID: 38028759 PMC: 10665574. DOI: 10.3389/fphys.2023.1281555.

The Molecular Mechanism and Therapeutic Application of Autophagy for Urological Disease.

Chueh K, Lu J, Juan T, Chuang S, Juan Y Int J Mol Sci. 2023; 24(19).

PMID: 37834333 PMC: 10573233. DOI: 10.3390/ijms241914887.

HOOKLESS1 acetylates AUTOPHAGY-RELATED PROTEIN18a to promote autophagy during nutrient starvation in Arabidopsis.

Huang L, Wen X, Jin L, Han H, Guo H Plant Cell. 2023; 36(1):136-157.

PMID: 37823521 PMC: 10734606. DOI: 10.1093/plcell/koad252.

References

Iwata A, Riley B, Johnston J, Kopito R . HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J Biol Chem. 2005; 280(48):40282-92. DOI: 10.1074/jbc.M508786200. View

He C, Klionsky D . Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet. 2009; 43:67-93. PMC: 2831538. DOI: 10.1146/annurev-genet-102808-114910. View

Rikiishi H . Autophagic and apoptotic effects of HDAC inhibitors on cancer cells. J Biomed Biotechnol. 2011; 2011:830260. PMC: 3100649. DOI: 10.1155/2011/830260. View

Marino G, Morselli E, Bennetzen M, Eisenberg T, Megalou E, Schroeder S . Longevity-relevant regulation of autophagy at the level of the acetylproteome. Autophagy. 2011; 7(6):647-9. DOI: 10.4161/auto.7.6.15191. View

Zou H, Wu Y, Navre M, Sang B . Characterization of the two catalytic domains in histone deacetylase 6. Biochem Biophys Res Commun. 2006; 341(1):45-50. DOI: 10.1016/j.bbrc.2005.12.144. View

Steffan J, Bodai L, PALLOS J, Poelman M, McCampbell A, Apostol B . Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature. 2001; 413(6857):739-43. DOI: 10.1038/35099568. View

Yang Z, Klionsky D . Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol. 2009; 22(2):124-31. PMC: 2854249. DOI: 10.1016/j.ceb.2009.11.014. View

Juhasz G, Puskas L, Komonyi O, Erdi B, Maroy P, Neufeld T . Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ. 2007; 14(6):1181-90. PMC: 2084463. DOI: 10.1038/sj.cdd.4402123. View

Dong H, Czaja M . Regulation of lipid droplets by autophagy. Trends Endocrinol Metab. 2011; 22(6):234-40. PMC: 3118855. DOI: 10.1016/j.tem.2011.02.003. View

10.

Geeraert C, Ratier A, Pfisterer S, Perdiz D, Cantaloube I, Rouault A . Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation. J Biol Chem. 2010; 285(31):24184-94. PMC: 2911293. DOI: 10.1074/jbc.M109.091553. View

11.

Yang J, Hung M . Deciphering the role of forkhead transcription factors in cancer therapy. Curr Drug Targets. 2011; 12(9):1284-90. PMC: 3149891. DOI: 10.2174/138945011796150299. View

12.

Sengupta A, Molkentin J, Yutzey K . FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem. 2009; 284(41):28319-28331. PMC: 2788882. DOI: 10.1074/jbc.M109.024406. View

13.

Levine B, Kroemer G . Autophagy in the pathogenesis of disease. Cell. 2008; 132(1):27-42. PMC: 2696814. DOI: 10.1016/j.cell.2007.12.018. View

14.

Piperno G, Fuller M . Monoclonal antibodies specific for an acetylated form of alpha-tubulin recognize the antigen in cilia and flagella from a variety of organisms. J Cell Biol. 1985; 101(6):2085-94. PMC: 2114011. DOI: 10.1083/jcb.101.6.2085. View

15.

Ravikumar B, Acevedo-Arozena A, Imarisio S, Berger Z, Vacher C, OKane C . Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet. 2005; 37(7):771-6. DOI: 10.1038/ng1591. View

16.

Reed N, Cai D, Blasius T, Jih G, Meyhofer E, Gaertig J . Microtubule acetylation promotes kinesin-1 binding and transport. Curr Biol. 2006; 16(21):2166-72. DOI: 10.1016/j.cub.2006.09.014. View

17.

Roccaro A, Sacco A, Jia X, Azab A, Maiso P, Ngo H . microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia. Blood. 2010; 116(9):1506-14. PMC: 2938840. DOI: 10.1182/blood-2010-01-265686. View

18.

Komatsu M, Waguri S, Koike M, Sou Y, Ueno T, Hara T . Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell. 2007; 131(6):1149-63. DOI: 10.1016/j.cell.2007.10.035. View

19.

Nucifora Jr F, Sasaki M, Peters M, Huang H, Cooper J, Yamada M . Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science. 2001; 291(5512):2423-8. DOI: 10.1126/science.1056784. View

20.

Pandey U, Batlevi Y, Baehrecke E, Taylor J . HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration. Autophagy. 2007; 3(6):643-5. DOI: 10.4161/auto.5050. View