High-cell-density Culture Strategies for Polyhydroxyalkanoate Production: a Review

Overview

Journal J Ind Microbiol Biotechnol

Publisher Oxford University Press

Specialty Biotechnology

Date 2013 Mar 5

PMID 23455696

Citations 17

Authors

Jaciane Lutz Ienczak

Willibaldo Schmidell

Glaucia Maria Falcao de Aragao

Affiliations

Soon will be listed here.

Abstract

This article gives an overview of high-cell-density cultures for polyhydroxyalkanoate (PHA) production and their modes of operation for increasing productivity. High cell densities are very important in PHA production mainly because this polymer is an intracellular product accumulated in various microorganisms, so a high cellular content is needed for the polymer production. This review describes relevant results from fed-batch, repeated batch, and continuous modes of operation without and with cell recycle for the production of these polymers by microorganisms. Finally, recombinant microorganisms for PHA production, as well future directions for PHA production, are discussed.

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