Steatocystoma Multiplex-a Rare Genetic Disorder: a Case Report and Review of the Literature

Overview

Journal J Clin Diagn Res

Specialty General Medicine

Date 2013 Mar 2

PMID 23449619

Citations 16

Authors

Hemlata T Kamra

Pradeep A Gadgil

Ajay G Ovhal

Rahul R Narkhede

Affiliations

Soon will be listed here.

Abstract

A 17 years old female presented with multiple asymptomatic cutaneous cysts all over body, sparing the head and neck region. The microscopic examination of the cysts showed the features of steatocystoma multiplex. This disorder, although it is asymptomatic, is a cosmetic threat to the patient. Only a few cases of the patients with an autosomal dominant mutation, who had keratin 17, have been reported. We are reporting here, a case of steatocystoma multiplex in a 17 years old female, along with its review of literature.

Citing Articles

A Facial Solitary Vellus Hair Cyst: A Rare Entity.

Ghosh Moulic A, Deshmukh P, Gaurkar S Cureus. 2024; 16(2):e54159.

PMID: 38496162 PMC: 10940956. DOI: 10.7759/cureus.54159.

Concurrent Occurrence of Trichilemmal Cyst and Nevus of Ota: Case Series.

Gowda Venkatesha R, Rajaram Mohan K, Sridhar Rao V, Fenn S, Rathan R Cureus. 2024; 16(1):e52439.

PMID: 38371070 PMC: 10871544. DOI: 10.7759/cureus.52439.

Benign Cutaneous Cysts: A Comprehensive Analysis of 1160 cases.

Chughtai A, Hashim M, Saleem R, Zafar G, Yasin R, Chughtai O Cureus. 2023; 15(9):e45548.

PMID: 37868536 PMC: 10586350. DOI: 10.7759/cureus.45548.

Huge Steatocystoma Multiplex with New Point Mutation in the Exon 1 of KRT 17 Gene.

Kim J, Park J, Sohng C, Jang Y, Lee S, Lee W Ann Dermatol. 2021; 30(5):633-635.

PMID: 33911497 PMC: 7992486. DOI: 10.5021/ad.2018.30.5.633.

A Case of Steatocystoma Multiplex in a Psoriatic Patient during Treatment with Anti-IL-12/23.

Marasca C, Megna M, Donnarumma M, Fontanella G, Cinelli E, Fabbrocini G Skin Appendage Disord. 2020; 6(5):309-311.

PMID: 33088817 PMC: 7548969. DOI: 10.1159/000507657.

References

Tomkova H, Fujimoto W, Arata J . Expression of keratins (K10 and K17) in steatocystoma multiplex, eruptive vellus hair cysts, and epidermoid and trichilemmal cysts. Am J Dermatopathol. 1997; 19(3):250-3. DOI: 10.1097/00000372-199706000-00008. View

Park K, Oh K, Noh T . Steatocystoma multiplex: mammographic and sonographic manifestations. AJR Am J Roentgenol. 2002; 180(1):271-4. DOI: 10.2214/ajr.180.1.1800271. View

Plewig G, Wolff H, Braun-Falco O . Steatocystoma multiplex: anatomic reevaluation, electron microscopy, and autoradiography. Arch Dermatol Res. 1982; 272(3-4):363-80. DOI: 10.1007/BF00509068. View

Chu D . Steatocystoma multiplex. Dermatol Online J. 2003; 9(4):18. View

HURLEY H, LOPRESTI P . Steatocystoma Multiplex. Arch Dermatol. 1965; 92(1):110-1. DOI: 10.1001/archderm.92.1.110b. View

Moretti de Lima A, Rocha S, Batista C, Reis C, Leal I, Azevedo L . Case for diagnosis. Steatocystoma multiplex. An Bras Dermatol. 2011; 86(1):165-6. DOI: 10.1590/s0365-05962011000100031. View

Wang X, Shi Y, Ye Y, Liu F, Jin W, Chen W . [Keratin 17 gene mutation in patients with steatocystoma multiplex]. Zhonghua Yi Xue Za Zhi. 2002; 81(9):540-3. View

Karen J, Heller M, Wee S, Mikkilineni R . Eruptive vellus hair cysts. Dermatol Online J. 2007; 13(1):14. View

Covello S, Smith F, Sillevis Smitt J, Paller A, Munro C, Jonkman M . Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2. Br J Dermatol. 1998; 139(3):475-80. DOI: 10.1046/j.1365-2133.1998.02413.x. View

10.

Mumcuoglu C, Gurel M, Kiremitci U, Turgut Erdemir A, Karakoca Y, Huten O . Er: yag laser therapy for steatocystoma multiplex. Indian J Dermatol. 2010; 55(3):300-1. PMC: 2965929. DOI: 10.4103/0019-5154.70690. View

11.

Choudhary S, Koley S, Salodkar A . A modified surgical technique for steatocystoma multiplex. J Cutan Aesthet Surg. 2010; 3(1):25-8. PMC: 2890132. DOI: 10.4103/0974-2077.63284. View

12.

Kim S, Park H, Oh S, Lee J, Cho B . A case of steatocystoma multiplex limited to the scalp. Ann Dermatol. 2010; 21(1):106-9. PMC: 2883360. DOI: 10.5021/ad.2009.21.1.106. View

13.

Gass J, Wilson N, Smith F, Lane E, McLean W, Rytina E . Steatocystoma multiplex, oligodontia and partial persistent primary dentition associated with a novel keratin 17 mutation. Br J Dermatol. 2009; 161(6):1396-8. DOI: 10.1111/j.1365-2133.2009.09383.x. View

14.

Smith F, Corden L, Rugg E, Ratnavel R, Leigh I, Moss C . Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex. J Invest Dermatol. 1997; 108(2):220-3. DOI: 10.1111/1523-1747.ep12335315. View