A Noninvasive Tumor Oxygenation Imaging Strategy Using Magnetic Resonance Imaging of Endogenous Blood and Tissue Water

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2013 Mar 1

PMID 23447121

Citations 14

Authors

Zhongwei Zhang

Rami R Hallac

Peter Peschke

Ralph P Mason

Affiliations

Soon will be listed here.

Abstract

Purpose: To present a novel imaging strategy for noninvasive measurement of tumor oxygenation using MR imaging of endogenous blood and tissue water.

Theory And Methods: The proposed approach for oxygen partial pressure (pO2) estimation is based on intravoxel incoherent motion diffusion MRI and the dependence of the blood R2 relaxation rate on the inter-echo spacing measured using a multiple spin-echo Carr-Purcell-Meiboom-Gill sequence and weak-field diffusion model. The accuracy of the approach was validated by comparison with (19)F MRI oximetry.

Results: The results in eight rats at 4.7 T showed that tumors have longer T1 (1980 ± 186 ms) and T2 (59 ± 9 ms) relaxation times, heterogeneous blood volume fraction (0.23 ± 0.1), oxygen saturation level (Y) (0.53 ± 0.12), and pO2 (36 ± 15 mmHg) distributions compared with normal muscle (T1 1480 ± 86 ms, T2 29 ± 2 ms, blood volume fraction 0.22 ± 0.03, Y 0.49 ± 0.06, and pO2 39 ± 5 mmHg). pO2 estimates based on the novel (1)H approach were essentially identical with (19)F observations.

Conclusion: The study indicates that noninvasive measurement of tumor pO2 using (1)H MRI derived multiparametric maps is feasible and could become a valuable tool to evaluate tumor hypoxia.

Citing Articles

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Imaging of Tumor Hypoxia With Radionuclide-Labeled Tracers for PET.

Huang Y, Fan J, Li Y, Fu S, Chen Y, Wu J Front Oncol. 2021; 11:731503.

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Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration.

Gorodetskii A, Eubank T, Driesschaert B, Poncelet M, Ellis E, Khramtsov V Sci Rep. 2019; 9(1):12093.

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Incorporating Oxygen-Enhanced MRI into Multi-Parametric Assessment of Human Prostate Cancer.

Zhou H, Hallac R, Yuan Q, Ding Y, Zhang Z, Xie X Diagnostics (Basel). 2017; 7(3).

PMID: 28837092 PMC: 5617948. DOI: 10.3390/diagnostics7030048.

Tumor physiological changes during hypofractionated stereotactic body radiation therapy assessed using multi-parametric magnetic resonance imaging.

Zhou H, Zhang Z, Denney R, Williams J, Gerberich J, Stojadinovic S Oncotarget. 2017; 8(23):37464-37477.

PMID: 28415581 PMC: 5514922. DOI: 10.18632/oncotarget.16395.

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