Primary Pulmonary Malignant Meningioma with Lymph Node and Liver Metastasis in a Centenary Woman, an Autopsy Case

Overview

Journal Virchows Arch

Specialties Cell Biology
Molecular Biology
Pathology

Date 2013 Feb 28

PMID 23443940

Citations 14

Authors

Catherine Weber

Sophie Pautex

Gilbert B Zulian

Marc Pusztaszeri

Johannes Alexander Lobrinus

Affiliations

Soon will be listed here.

Abstract

Primary meningiomas arising outside the central nervous system are very rare. They have been reported in the head and neck region, in the thorax, the retroperitoneum, and the pelvis. Usually, they behave as slow-growing tumors with a good prognosis. Herein, we report an autopsy case of a 108-year-old woman, known for a right-sided slowly growing lung nodule for 39 years. Death was attributed to cachexia. At post-mortem, a 15-cm mass was present in the right inferior lobe of the lung, associated with an ipsilateral hilar lymphadenopathy, and another 10-cm mass in the liver. Histology revealed a WHO grade III meningioma. No tumor was observed in the cranial cavity. This case illustrates a rare location of meningioma and highlights its biological behavior, with a very slow progression from a most probably benign tumor to a malignant lesion with metastasis over four decades.

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